dc.contributor
Institut Català de la Salut
dc.contributor
[Aceituno L] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Departament de Medicina, Universitat Autònoma de Barcelona, Bellaterra, Spain. [Nuñez-Conde A] Internal Medicine Department, Mútua Terrassa University Hospital, Terrassa, Barcelona, Spain. [Serra-Pladevall J] Microbiology Department, Vic Hospital, Vic, Spain. [Viñado B] Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Castella E] Servei de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Escolà-Vergé L] Infectious Diseases Unit, Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. CIBERINFEC, Instituto de Salud Carlos III, Barcelona, Spain. [Pigrau C, Falcó V] Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Len O] CIBERINFEC, Instituto de Salud Carlos III, Barcelona, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Nuñez-Conde, A.
dc.contributor.author
Castella Fierro, Eva
dc.contributor.author
Aceituno, Laia
dc.contributor.author
Escolà-Vergé, Laura
dc.contributor.author
Pigrau, Carlos
dc.contributor.author
Len, Oscar
dc.contributor.author
Falcó, Vicenç
dc.contributor.author
VIÑADO, BELEN
dc.contributor.author
Serra-Pladevall, Judit
dc.date.accessioned
2025-10-24T10:32:40Z
dc.date.available
2025-10-24T10:32:40Z
dc.date.issued
2024-08-21T07:38:26Z
dc.date.issued
2024-08-21T07:38:26Z
dc.date.issued
2024-06-10
dc.identifier
Aceituno L, Nuñez-Conde A, Serra-Pladevall J, Viñado B, Castella E, Escolà-Vergé L, et al. Oral quinolones versus intravenous β-lactam for the treatment of acute focal bacterial nephritis: a retrospective cohort study. Eur J Clin Microbiol Infect Dis. 2024 May;43:1559–1567.
dc.identifier
https://hdl.handle.net/11351/11850
dc.identifier
10.1007/s10096-024-04871-2
dc.identifier
001243668900002
dc.identifier.uri
https://hdl.handle.net/11351/11850
dc.description.abstract
Acute focal pyelonephritis; Quinolones; Urinary tract infections
dc.description.abstract
Pielonefritis focal aguda; Quinolones; Infeccions del tracte urinari
dc.description.abstract
Pielonefritis focal aguda; Quinolonas; Infecciones del tracto urinario
dc.description.abstract
Background
Evidence regarding the best antibiotic regimen and the route of administration to treat acute focal bacterial nephritis (AFBN) is scarce. The aim of the present study was to compare the effectiveness of intravenous (IV) β-lactam antibiotics versus oral quinolones.
Methods
This is a retrospective single centre study of patients diagnosed with AFBN between January 2017 and December 2018 in Hospital Universitari Vall d’Hebron, Barcelona (Spain). Patients were identified from the diagnostic codifications database. Patients treated with oral quinolones were compared with those treated with IV β-lactam antibiotics. Therapeutic failure was defined as death, relapse, or evolution to abscess within the first 30 days.
Results
A total of 264 patients fulfilled the inclusion criteria. Of those, 103 patients (39%) received oral ciprofloxacin, and 70 (26.5%) IV β-lactam. The most common isolated microorganism was Escherichia coli (149, 73.8%) followed by Klebsiella pneumoniae (26, 12.9%). Mean duration of treatment was 21.3 days (SD 7.9). There were no statistical differences regarding therapeutic failure between oral quinolones and IV β-lactam treatment (6.6% vs. 8.7%, p = 0.6). Out of the 66 patients treated with intravenous antibiotics, 4 (6.1%) experienced an episode of phlebitis and 1 patient (1.5%) an episode of catheter-related bacteraemia.
Conclusions
When susceptible, treatment of AFBN with oral quinolones is as effective as IV β-lactam treatment with fewer adverse events.
dc.description.abstract
Open Access Funding provided by Universitat Autonoma de Barcelona.
dc.format
application/pdf
dc.relation
European Journal of Clinical Microbiology & Infectious Diseases;43
dc.relation
https://doi.org/10.1007/s10096-024-04871-2
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Avaluació de resultats (Assistència sanitària)
dc.subject
Malalties bacterianes - Tractament
dc.subject
Medicaments antibacterians - Ús terapèutic
dc.subject
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Infective Agents::Anti-Bacterial Agents
dc.subject
Other subheadings::Other subheadings::/therapeutic use
dc.subject
DISEASES::Bacterial Infections and Mycoses::Bacterial Infections
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Other subheadings::Other subheadings::Other subheadings::/drug therapy
dc.subject
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinfecciosos::antibacterianos
dc.subject
Otros calificadores::Otros calificadores::/uso terapéutico
dc.subject
ENFERMEDADES::infecciones bacterianas y micosis::infecciones bacterianas
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
dc.title
Oral quinolones versus intravenous β-lactam for the treatment of acute focal bacterial nephritis: a retrospective cohort study
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
