SEOM-GEIS Spanish clinical guidelines for the management of soft‑tissue sarcomas (2024)

Abstract

Rare cancer; Sarcoma; Soft-tissue sarcoma

Cáncer raro; Sarcoma; Sarcoma de tejidos blandos

Càncer rar; Sarcoma; Sarcoma de teixits tous

Soft-tissue sarcomas are rare, diverse malignant tumors of mesenchymal origin, requiring diagnosis and treatment by a specialized multidisciplinary team. Initial assessment includes radiology and biopsy, followed by wide surgical resection with clear margins for localized cases. Radiotherapy is recommended for large, deep, high-grade tumors or after incomplete resection, while perioperative chemotherapy may be considered for high-risk cases. In oligometastatic disease, combining local and systemic therapies is an option. Anthracycline-based chemotherapy is the first-line treatment in advanced disease, though other drugs show efficacy in certain subtypes. Given the limited options, enrolling in clinical trials is advised for patients needing further treatment.