Sistema de Salut de Catalunya
Institut Català de la Salut
[Kopetz S] University of Texas MD Anderson Cancer Center, Houston, TX, USA. [Murphy DA] Formerly Pfizer, La Jolla, CA, USA. [Pu J] Formerly Pfizer, New York, NY, USA. [Ciardiello F] University of Campania Luigi Vanvitelli, Naples, Italy. [Desai J] Peter MacCallum Cancer Centre, Melbourne, VIC, Australia. [Van Cutsem E] University Hospitals Gasthuisberg Leuven and KU Leuven, Leuven, Belgium. [Tabernero J] Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. University of Vic – Central University of Catalonia, Vic, Spain
Vall d'Hebron Barcelona Hospital Campus
2025-07-08T10:52:11Z
2025-07-08T10:52:11Z
2025
Colorectal cancer; Mutation
Càncer colorectal; Mutació
Cáncer colorrectal; Mutación
What is this summary about? This summary discusses the genetic and molecular changes in tumors of participants with BRAF V600E–mutant metastatic colorectal cancer who were treated with encorafenib plus cetuximab, with or without binimetinib, in the BEACON study. What were the results? Encorafenib plus cetuximab, with or without binimetinib, reduced the risk of participants dying compared with cetuximab plus chemotherapy, regardless of genetic or molecular colorectal cancer subtypes. The study also found genetic and molecular changes in the participants’ tumors during treatment that were associated with how long they lived. What do the results of the study mean? The types of genetic and molecular changes that occur during treatment in participants’ tumors can affect their response to treatment with BRAF and MEK inhibitors.
This manuscript was funded by Pfizer.
Article
Published version
English
Anomalies cromosòmiques; Recte - Càncer - Tractament; Còlon - Càncer - Tractament; DISEASES::Neoplasms::Neoplasms by Site::Digestive System Neoplasms::Gastrointestinal Neoplasms::Intestinal Neoplasms::Colorectal Neoplasms; Other subheadings::Other subheadings::Other subheadings::/drug therapy; PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Mutation; ENFERMEDADES::neoplasias::neoplasias por localización::neoplasias del sistema digestivo::neoplasias gastrointestinales::neoplasias intestinales::neoplasias colorrectales; Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia; FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::mutación
Taylor & Francis
Future Oncology;21(14)
https://doi.org/10.1080/14796694.2025.2498880
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Articles científics - HVH [3440]
