Sistema de Salut de Catalunya
Institut Català de la Salut
[Santamarina E, Alpuente A]Unitat d’Epilèpsia, Servei de Neurologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Maisterra O] Unitat Neurovascular, Servei de Neurologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sueiras M] Unitat d’Electroencefalografia, Servei de Neurofisiologia Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sarria S] Unitat MRI, Servei de Neuroradiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Guzman L] Unitat d’Electroencefalografia, Servei de Neurofisiologia Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Abraira L, Salas-Puig J, Toledo M] Unitat d’Epilèpsia, Servei de Neurologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
Vall d'Hebron Barcelona Hospital Campus
2019-04-09T11:22:06Z
2019-04-09T11:22:06Z
2019-02-07
MELAS; Perampanel; Status epilepticus
MELAS; Perampanel; Estatus epilèptic
MELAS; Perampanel; Status epiléptico
To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI. In our patients, PER was an effective option in SE associated with MELAS syndrome.
Article
Published version
English
Epilèpsia - Tractament; Encefalitis - Tractament; Piridina; DISEASES::Nervous System Diseases::Neurologic Manifestations::Seizures::Status Epilepticus; DISEASES::Musculoskeletal Diseases::Muscular Diseases::Mitochondrial Myopathies::Mitochondrial Encephalomyopathies::MELAS Syndrome; Other subheadings::Other subheadings::Other subheadings::/drug therapy; CHEMICALS AND DRUGS::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyridines::Pyridones; ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::convulsiones::estado epiléptico; ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miopatías mitocondriales::encefalomiopatías mitocondriales::síndrome MELAS; Otros calificadores::Otros calificadores::Otros calificadores::/tratamiento farmacológico; COMPUESTOS QUÍMICOS Y DROGAS::compuestos heterocíclicos::compuestos heterocíclicos de 1 anillo::piridinas::piridonas
Elsevier
Epilepsy and Behavior Case Reports;11
https://www.sciencedirect.com/science/article/pii/S2213323218301695?via%3Dihub#!
Attribution-NonCommercial-NoDerivatives 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
Articles científics - HVH [3439]
