dc.contributor
Institut Català de la Salut
dc.contributor
[Santamarina E, Alpuente A]Unitat d’Epilèpsia, Servei de Neurologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Maisterra O] Unitat Neurovascular, Servei de Neurologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sueiras M] Unitat d’Electroencefalografia, Servei de Neurofisiologia Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Sarria S] Unitat MRI, Servei de Neuroradiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Guzman L] Unitat d’Electroencefalografia, Servei de Neurofisiologia Clínica, Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Abraira L, Salas-Puig J, Toledo M] Unitat d’Epilèpsia, Servei de Neurologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Santamarina Pérez, Estevo
dc.contributor.author
Maisterra Santos, Olga
dc.contributor.author
Sueiras Gil, Maria
dc.contributor.author
Sarria Estrada, Silvana Isabel
dc.contributor.author
Guzmán García, Lorena Carolina
dc.contributor.author
Salas Puig, Xavier
dc.contributor.author
Toledo Argany, Manuel
dc.contributor.author
Abraira del Fresno, Laura
dc.contributor.author
Alpuente Ruiz, Alicia
dc.date.accessioned
2025-10-24T10:32:35Z
dc.date.available
2025-10-24T10:32:35Z
dc.date.issued
2019-04-09T11:22:06Z
dc.date.issued
2019-04-09T11:22:06Z
dc.date.issued
2019-02-07
dc.identifier
Santamarina E, Alpuente A, Maisterra O, Sueiras M, Sarria S, Guzman L, et al. Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome. Epilepsy Behav Case Report. 2019;11:92–5.
dc.identifier
https://hdl.handle.net/11351/4033
dc.identifier
10.1016/j.ebcr.2019.01.008
dc.identifier.uri
https://hdl.handle.net/11351/4033
dc.description.abstract
MELAS; Perampanel; Status epilepticus
dc.description.abstract
MELAS; Perampanel; Estatus epilèptic
dc.description.abstract
MELAS; Perampanel; Status epiléptico
dc.description.abstract
To our knowledge, there are no reports of status epilepticus (SE) associated with mitochondrial diseases and treated with perampanel (PER). We present three cases of patients with refractory SE associated with MELAS syndrome who responded favorably to PER. All cases were diagnosed as non-convulsive SE (focal without impairment of level of consciousness). After an initial treatment with other anti-seizure drugs, PER was added in all cases (8, 16 and 12 mg) and cessation of SE was observed within the next 4-8 hours. All the cases involved a stroke-like lesion present on brain MRI. In our patients, PER was an effective option in SE associated with MELAS syndrome.
dc.format
application/pdf
dc.relation
Epilepsy and Behavior Case Reports;11
dc.relation
https://www.sciencedirect.com/science/article/pii/S2213323218301695?via%3Dihub#!
dc.rights
Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Epilèpsia - Tractament
dc.subject
Encefalitis - Tractament
dc.subject
DISEASES::Nervous System Diseases::Neurologic Manifestations::Seizures::Status Epilepticus
dc.subject
DISEASES::Musculoskeletal Diseases::Muscular Diseases::Mitochondrial Myopathies::Mitochondrial Encephalomyopathies::MELAS Syndrome
dc.subject
Other subheadings::Other subheadings::Other subheadings::/drug therapy
dc.subject
CHEMICALS AND DRUGS::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyridines::Pyridones
dc.subject
ENFERMEDADES::enfermedades del sistema nervioso::manifestaciones neurológicas::convulsiones::estado epiléptico
dc.subject
ENFERMEDADES::enfermedades musculoesqueléticas::enfermedades musculares::miopatías mitocondriales::encefalomiopatías mitocondriales::síndrome MELAS
dc.subject
Otros calificadores::Otros calificadores::Otros calificadores::/tratamiento farmacológico
dc.subject
COMPUESTOS QUÍMICOS Y DROGAS::compuestos heterocíclicos::compuestos heterocíclicos de 1 anillo::piridinas::piridonas
dc.title
Perampanel: A therapeutic alternative in refractory status epilepticus associated with MELAS syndrome
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
