Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources

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RECERCAT Home > Sistema de Salut de Catalunya > IDIAP Jordi Gol - IDIAP > Articles científics - IDIAP > View document

To access the full text documents, please follow this link: http://hdl.handle.net/11351/4127

dc.contributor	Institut Català de la Salut
dc.contributor	[Forns J, Cainzos-Achirica M, Castellsagué J, Perez-Gutthann S] Epidemiology, RTI Health Solutions, Barcelona, Spain. [Hellfritzsch M, Hallas J, Pottegård A] Clinical Pharmacology and Pharmacy, Department of Public Health, University of Southern Denmark, Odense, Denmark. [Morros R, Giner-Soriano M] Fundació Institut Universitari per a la recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Barcelona, Spain. Institut Català de la Salut, Barcelona, Spain. [Poblador-Plou B, Prados-Torres A] EpiChron, Instituto Aragonés de Ciencias de la Salud, (IACS), IIS Aragón, REDISSEC ISCIII, Zaragoza, Spain. [Cortés J] Departament d'Estadística i Investigació Operativa, Universitat Politècnica de Catalunya, Barcelona, Spain. [Jacquot E, Deltour N] Pharmacoepidemiology Department, Les Laboratoires Servier, Paris, France. [Pladevall M] Epidemiology, RTI Health Solutions, Barcelona, Spain. The Center for Health Policy and Health Services Research, Henry Ford Health System, Detroit, MI, USA.
dc.contributor	IDIAP Jordi Gol
dc.contributor.author	Forns, Joan
dc.contributor.author	Cainzos-Achirica, Miguel
dc.contributor.author	Hellfritzsch, Maja
dc.contributor.author	Morros, Rosa
dc.contributor.author	Poblador-Plou, Beatriz
dc.contributor.author	Hallas, Jesper
dc.contributor.author	Giner-Soriano, Maria
dc.contributor.author	Prados-Torres, Alexandra
dc.contributor.author	Pottegård, Anton
dc.contributor.author	Cortés, Jordi
dc.contributor.author	Castellsagué, Jordi
dc.contributor.author	Jacquot, Emmanuelle
dc.contributor.author	Deltour, Nicolas
dc.contributor.author	Perez-Gutthann, Susana
dc.contributor.author	Pladevall-Vila, Manel
dc.date	2019-06-11T08:14:52Z
dc.date	2019-06-11T08:14:52Z
dc.date	2019-06-06
dc.identifier	Forns J, Cainzos-Achirica M, Hellfritzsch M, Morros R, Poblador-Plou B, Giner-Soriano M, et al. Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources. Pharmacoepidemiol Drug Saf. 2019.
dc.identifier	1099-1557
dc.identifier	http://hdl.handle.net/11351/4127
dc.identifier	10.1002/pds.4803
dc.identifier	31172633
dc.identifier.uri	http://hdl.handle.net/11351/4127
dc.format	application/pdf
dc.language	eng
dc.publisher	Wiley Online Library
dc.relation	Pharmacoepidemiology and Drug Safety;
dc.relation	https://onlinelibrary.wiley.com/doi/full/10.1002/pds.4803
dc.rights	Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights	http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights	info:eu-repo/semantics/openAccess
dc.source	Scientia
dc.subject	Farmacoepidemiologia
dc.subject	Antidepressius
dc.subject	Registres mèdics
dc.subject	Insuficiència hepàtica - Diagnòstic
dc.subject	PUBLIC HEALTH::Epidemiology and Biostatistics::Biostatistics::Health Classifications::International Classification of Diseases
dc.subject	Other subheadings::Other subheadings::Other subheadings::/utilization
dc.subject	DISEASES::Digestive System Diseases::Liver Diseases::Hepatic Insufficiency::Liver Failure::Liver Failure, Acute
dc.subject	CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Psychotropic Drugs::Antidepressive Agents
dc.subject	DISCIPLINES AND OCCUPATIONS::Health Occupations::Medicine::Public Health::Epidemiology::Health Occupations::Pharmacoepidemiology
dc.subject	SALUD PÚBLICA::epidemiología y bioestadística::bioestadística::clasificaciones en salud::Clasificación Internacional de Enfermedades
dc.subject	Otros calificadores::Otros calificadores::Otros calificadores::/utilización
dc.subject	ENFERMEDADES::enfermedades del sistema digestivo::enfermedades hepáticas::insuficiencia hepática::fracaso hepático::fracaso hepático agudo
dc.subject	COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::fármacos psicotrópicos::antidepresivos
dc.subject	DISCIPLINAS Y OCUPACIONES::profesiones sanitarias::medicina::salud pública::epidemiología::profesiones sanitarias::farmacoepidemiología
dc.title	Validity of ICD-9 and ICD-10 codes used to identify acute liver injury: A study in three European data sources
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Acute liver injury; Antidepressants; Pharmacoepidemiology
dc.description.abstract	Lesió hepàtica aguda; Antidepressius; Farmacoepidemiologia
dc.description.abstract	Lesión hepática aguda; Antidepresivos; Farmacoepidemiología
dc.description.abstract	PURPOSE: Validating cases of acute liver injury (ALI) in health care data sources is challenging. Previous validation studies reported low positive predictive values (PPVs). METHODS: Case validation was undertaken in a study conducted from 2009 to 2014 assessing the risk of ALI in antidepressants users in databases in Spain (EpiChron and SIDIAP) and the Danish National Health Registers. Three ALI definitions were evaluated: primary (specific hospital discharge codes), secondary (specific and nonspecific hospital discharge codes), and tertiary (specific and nonspecific hospital and outpatient codes). The validation included review of patient profiles (EpiChron and SIDIAP) and of clinical data from medical records (EpiChron and Denmark). ALI cases were confirmed when liver enzyme values met a definition by an international working group. RESULTS: Overall PPVs (95% CIs) for the study ALI definitions were, for the primary ALI definition, 84% (60%-97%) (EpiChron), 60% (26%-88%) (SIDIAP), and 74% (60%-85%) (Denmark); for the secondary ALI definition, 65% (45%-81%) (EpiChron), 40% (19%-64%) (SIDIAP), and 70% (64%-77%) (Denmark); and for the tertiary ALI definition, 25% (18%-34%) (EpiChron), 8% (7%-9%) (SIDIAP), and 47% (42%-52%) (Denmark). The overall PPVs were higher for specific than for nonspecific codes and for hospital discharge than for outpatient codes. The nonspecific code "unspecified jaundice" had high PPVs in Denmark. CONCLUSIONS: PPVs obtained apply to patients using antidepressants without preexisting liver disease or ALI risk factors. To maximize validity, studies on ALI should prioritize hospital specific discharge codes and should include hospital codes for unspecified jaundice. Case validation is required when ALI outpatient cases are considered.

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