Sistema de Salut de Catalunya
Pascual García, Mónica
Bonfill Teixidor, Ester
Planas Rigol, Ester
Iurlaro, Raffaella
Arias Piñeiro, Alexandra
Cuartas Maza, Ma Isabel
Sala Hojman, Ada
Escudero Monreal, Laura
Martínez Ricarte, Francisco Ramón
Huber Ruano, Isabel
Nuciforo, Paolo Giovanni
Braña Garcia, Irene
Garralda Cabanas, Elena
Vieito Villar, Maria
Espejo Ruiz, Carmen
Sahuquillo Barris, Joan
Tabernero Caturla, Josep
Seoane Suarez, Joan
Rubio-Perez, Carlota
Institut Català de la Salut
[Pascual-García M, Bonfill-Teixidor E] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. CIBERONC, Madrid, Spain. [Planas-Rigol E, Rubio-Perez C, Iurlaro R, Arias A, Cuartas I, Sala-Hojman A, Escudero L, Huber-Ruano I, Nuciforo P, Braña I, Garralda E, Vieito M] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Martínez-Ricarte F, Espejo C, Sahuquillo J] Vall d’Hebron Institut de Recerca, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. [Tabernero J] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. CIBERONC, Madrid, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. [Seoane J] Vall d'Hebron Institut d'Oncologia, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. CIBERONC, Madrid, Spain. Universitat Autònoma de Barcelona, Cerdanyola del Vallès, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
Vall d'Hebron Barcelona Hospital Campus
2019-07-31T10:01:10Z
2019-07-31T10:01:10Z
2019-06-11
Càncer; Macròfags associats al tumor: LIF; CD8
Cáncer; Macrófagos asociados al tumor; CD8
Cancer; Tumor-associated macrophages; CD8
Cancer response to immunotherapy depends on the infiltration of CD8+ T cells and the presence of tumor-associated macrophages within tumors. Still, little is known about the determinants of these factors. We show that LIF assumes a crucial role in the regulation of CD8+ T cell tumor infiltration, while promoting the presence of protumoral tumor-associated macrophages. We observe that the blockade of LIF in tumors expressing high levels of LIF decreases CD206, CD163 and CCL2 and induces CXCL9 expression in tumor-associated macrophages. The blockade of LIF releases the epigenetic silencing of CXCL9 triggering CD8+ T cell tumor infiltration. The combination of LIF neutralizing antibodies with the inhibition of the PD1 immune checkpoint promotes tumor regression, immunological memory and an increase in overall survival.
English
Medicaments antineoplàstics; Cèl·lules T - Immunologia; Citocines - Immunologia; Tumors - Tractament; DISEASES::Neoplasms; Other subheadings::Other subheadings::Other subheadings::/drug therapy; CHEMICALS AND DRUGS::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Leukemia Inhibitory Factor; ANATOMY::Cells::Blood Cells::Leukocytes::Leukocytes, Mononuclear::Lymphocytes::T-Lymphocytes::CD8-Positive T-Lymphocytes; Other subheadings::Other subheadings::Other subheadings::/immunology; ENFERMEDADES::neoplasias; Otros calificadores::Otros calificadores::Otros calificadores::/tratamiento farmacológico; COMPUESTOS QUÍMICOS Y DROGAS::aminoácidos, péptidos y proteínas::péptidos::péptidos y proteínas de señalización intercelular::citocinas::factor inhibidor de la leucemia; ANATOMÍA::células::células sanguíneas::leucocitos::leucocitos mononucleares::linfocitos::linfocitos T::linfocitos T CD8-positivos; Otros calificadores::Otros calificadores::Otros calificadores::/inmunología
Nature Research
Nature Communications;10(1)
https://www.nature.com/articles/s41467-019-10369-9
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
Articles científics - HVH [3370]
Articles científics - VHIR [1654]
