Open-access quantitative MRI data of the spinal cord and reproducibility across participants, sites and manufacturers

Other authors

Institut Català de la Salut

[Cohen-Adad J] NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada. Functional Neuroimaging Unit, CRIUGM, Université de Montréal, Montreal, QC, Canada. Mila - Quebec AI Institute, Montreal, QC, Canada. [Alonso-Ortiz E] NeuroPoly Lab, Institute of Biomedical Engineering, Polytechnique Montreal, Montreal, QC, Canada. [Abramovic M, Arneitz C] Department of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland. [Atcheson N] Centre for Advanced Imaging, The University of Queensland, Brisbane, Australia. [Barlow L] Department of Radiology, University of British Columbia, Vancouver, BC, Canada. [Grussu F] NMR Research Unit, Queen Square MS Centre, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, UK. Radiomics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Pareto D, Rovira À] Secció de Neuroradiologia, Vall d’Hebron Hospital Universitri, Barcelona, Spain

Vall d'Hebron Barcelona Hospital Campus

Publication date

2022-05-02T11:59:13Z

2022-05-02T11:59:13Z

2021-08-16



Abstract

Databases; Imaging techniques; Spinal cord diseases


Bases de datos; Tècnicas de imagen; Enfermedades de la médula espinal


Bases de dades; Tècniques d'imatge; Malalties de la medul·la espinal


In a companion paper by Cohen-Adad et al. we introduce the spine generic quantitative MRI protocol that provides valuable metrics for assessing spinal cord macrostructural and microstructural integrity. This protocol was used to acquire a single subject dataset across 19 centers and a multi-subject dataset across 42 centers (for a total of 260 participants), spanning the three main MRI manufacturers: GE, Philips and Siemens. Both datasets are publicly available via git-annex. Data were analysed using the Spinal Cord Toolbox to produce normative values as well as inter/intra-site and inter/intra-manufacturer statistics. Reproducibility for the spine generic protocol was high across sites and manufacturers, with an average inter-site coefficient of variation of less than 5% for all the metrics. Full documentation and results can be found at https://spine-generic.rtfd.io/. The datasets and analysis pipeline will help pave the way towards accessible and reproducible quantitative MRI in the spinal cord.

Document Type

Article


Published version

Language

English

Publisher

Nature Research

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Rights

Attribution 4.0 International

http://creativecommons.org/licenses/by/4.0/

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