dc.contributor
Institut Català de la Salut
dc.contributor
[Suarez C, Marmolejo D, Valdivia A, Morales-Barrera R, Gonzalez M, Mateo J, Carles J] Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Semidey ME] Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Lorente D, Trilla E] Servei d'Urologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.contributor
Vall d'Hebron Barcelona Hospital Campus
dc.contributor.author
Suárez Rodríguez, Cristina
dc.contributor.author
Marmolejo Castañeda, David
dc.contributor.author
Valdivia Bustamante, Augusto Alejandro
dc.contributor.author
Morales Barrera, Rafael
dc.contributor.author
González Rodríguez, Macarena
dc.contributor.author
Mateo Valderrama, Joaquim
dc.contributor.author
Lorente García, David
dc.contributor.author
Trilla Herrera, Enric
dc.contributor.author
Carles Galceran, Joan
dc.contributor.author
Semidey Raven, Maria Eugenia
dc.date.issued
2022-12-20T11:31:20Z
dc.date.issued
2022-12-20T11:31:20Z
dc.date.issued
2022-10-04
dc.identifier
Suarez C, Marmolejo D, Valdivia A, Morales-Barrera R, Gonzalez M, Mateo J, et al. Update in collecting duct carcinoma: Current aspects of the clinical and molecular characterization of an orphan disease. Front Oncol. 2022 Oct 4;12:970199.
dc.identifier
https://hdl.handle.net/11351/8697
dc.identifier
10.3389/fonc.2022.970199
dc.identifier
000872081400001
dc.description.abstract
Bellini carcinoma; Clear-cell carcinoma; Collecting duct
dc.description.abstract
Carcinoma de Bellini; Carcinoma de cèl·lules clares; Conducte col·lector
dc.description.abstract
Carcinoma de Bellini; Carcinoma de células claras; Conducto colector
dc.description.abstract
Collecting duct renal cell carcinoma (cdRCC), which until recently was thought to arise from the collecting ducts of Bellini in the renal medulla, is a rare and aggressive type of non-clear renal cell carcinoma (ncRCC), accounting for 1% of all renal tumors and with nearly 50% of patients being diagnosed with Stage IV disease. The median overall survival in this setting is less than 12 months. Several regimens of chemotherapies had been used based on morphologic and cytogenetic similarities with urothelial cell carcinoma described previously, although the prognosis still remains poor. The use of targeted therapies also did not result in favorable outcomes. Recent works using NGS have highlighted genomic alterations in SETD2, CDKN2A, SMARCB1, and NF2. Moreover, transcriptomic studies have confirmed the differences between urothelial carcinoma and cdRCC, the possible true origin of this disease in the distal convoluted tubule (DCT), differentiating from other RCC (e.g., clear cell and papillary) that derive from the proximal convoluted tubule (PCT), and enrichment in immune cells that may harbor insights in novel treatment strategies with immunotherapy and target agents. In this review, we update the current aspects of the clinical, molecular characterization, and new targeted therapeutic options for Collecting duct carcinoma and highlight the future perspectives of treatment in this setting.
dc.format
application/pdf
dc.publisher
Frontiers Media
dc.relation
Frontiers in Oncology;12
dc.relation
https://doi.org/10.3389/fonc.2022.970199
dc.rights
Attribution 4.0 International
dc.rights
http://creativecommons.org/licenses/by/4.0/
dc.rights
info:eu-repo/semantics/openAccess
dc.subject
Ronyons - Càncer - Immunoteràpia
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Càncer - Aspectes moleculars
dc.subject
DISEASES::Neoplasms::Neoplasms::Neoplasms by Site::Urogenital Neoplasms::Urologic Neoplasms::Kidney Neoplasms::Carcinoma, Renal Cell
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Other subheadings::Other subheadings::/therapy
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ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Biological Therapy::Immunomodulation::Immunotherapy
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ANATOMY::Urogenital System::Urinary Tract::Kidney::Nephrons::Kidney Tubules::Kidney Tubules, Collecting
dc.subject
ENFERMEDADES::neoplasias::neoplasias::neoplasias por localización::neoplasias urogenitales::neoplasias urológicas::neoplasias renales::carcinoma de células renales
dc.subject
Otros calificadores::Otros calificadores::/terapia
dc.subject
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::terapia biológica::inmunomodulación::inmunoterapia
dc.subject
ANATOMÍA::sistema urogenital::sistema urinario::riñón::nefronas::túbulos renales::túbulos renales colectores
dc.title
Update in collecting duct carcinoma: Current aspects of the clinical and molecular characterization of an orphan disease
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
