Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke

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Title:	Genetically-defined deficiency of mannose-binding lectin is associated with protection after experimental stroke in mice and outcome in human stroke
Author:	Cervera Álvarez, Álvaro; Planas Obradors, Anna Maria; Justicia Mercader, Carles; Urra, Xabier; Jensenius, Jens C.; Torres Peraza, Jesús Fernando; Lozano Soto, Francisco; Chamorro Sánchez, Ángel
Other authors:	Universitat de Barcelona
Abstract:	The complement system is a major effector of innate immunity that has been involved in stroke brain damage. Complement activation occurs through the classical, alternative and lectin pathways. The latter is initiated by mannose-binding lectin (MBL) and MBL-associated serine proteases (MASPs). Here we investigated whether the lectin pathway contributes to stroke outcome in mice and humans.
Subject(s):	-Enzims proteolítics -Infart cerebral -Immunitat -Models animals en la investigació -Proteolytic enzymes -Cerebral infarctio -Immunity -Animal models in research
Rights:	cc-by (c) Cervera Álvarez, Álvaro et al., 2010 http://creativecommons.org/licenses/by/3.0/es
Document type:	Article Article - Published version
Published by:	Public Library of Science (PLoS)
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