Molecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer

Home | About RECERCAT | Contact

Català | Castellano

All of RECERCAT

By Communities &
Collections By Defense Date By Authors By Titles By Subject

This Collection

By Defense Date By Authors By Titles By Subject

Statistics

View Statistics All RECERCAT

My RECERCAT

Other repositories directory

RECERCAT Home > Universitat de Barcelona > Química Inorgànica i Orgànica > Articles publicats en revistes (Química Inorgànica i Orgànica) > View document

To access the full text documents, please follow this link: http://hdl.handle.net/2445/97402

Title:	Molecular interplay betweeen cáncer cell fatty acid metabolism and oncogenic signaling as resource for novel treatment strategies against ovarian cancer
Author:	Wagner, Renate; Veigel, Daniel; Prostling, K.; Stübiger, Gerald; Grusch, Michael; Weghuber, J.; Singer, C.; Karlic, H.; Colomer, Ramón; López-Rodríguez, María Luz; Benhamú, Bellinda; Hegardt, Fausto; Serra i Cucurull, Dolors; García Gómez, Jordi; Valent, Peter; Grunt, Thomas
Other authors:	Universitat de Barcelona
Abstract:	The metabolic oncogene fatty acid synthase (FASN) is overexpressed in 80% of ovarian cancers (OC) and indicates poor prognosis. Exposure of OC to inhibitors of FASN elicits a complex stress response that interferes with receptor-PI3K-mTORC1 signaling (briefly designated 'PI3K pathway'). Here we demonstrate that FASN inhibitors capitalize on multiple mechanisms to interfere with the PI3K pathway, and that silencing this cascade is crucial for the anticancer action of the drugs.
Subject(s):	-Trompes de Fal·lopi -Càncer d'ovari -Medicaments antineoplàstics -Àcids grassos -Fallopian tubes -Ovarian cancer -Antineoplastic agents -Fatty acids
Rights:	cc-by-nc-nd (c) Elsevier B.V., 2015 http://creativecommons.org/licenses/by-nc-nd/3.0/es
Document type:	Article Article - Accepted version
Published by:	Elsevier B.V.
Share:

Show full item record

Related documents

Other documents of the same author

Fatty acid synthase is a metabolic marker of cell proliferation rather than malignancy in ovarian cancer and its precursor cells

Veigel, Daniel; Wagner, Renate; Stübiger, Gerald; Wuczkowski, Michael; Filipits, Martin; Horvat, Reinhard; Benhamú, Bellinda; López-Rodríguez, María Luz; Leisser, Asha; Valent, Peter; Grusch, Michael; Hegardt, Fausto; García Gómez, Jordi; Serra i Cucurull, Dolors; Auersperg, Nelly; Colomer, Ramón; Grunt, Thomas

(−)-UB006: A new fatty acid synthase inhibitor and cytotoxic agent without anorexic side effects

Makowski, Kamil; Mir Bonnín, Joan Francesc; Mera Nanín, Paula; Ariza Piquer, Xavier; Asins Muñoz, Guillermina; Hegardt, Fausto; Herrero Rodríguez, Laura; García Gómez, Jordi; Serra i Cucurull, Dolors

A novel inhibitor of fatty acid synthase shows activity against HER2+ breast cancer xenografts and is active in anti-HER2 drug-resistant cell lines

Puig, Teresa; Puig, Teresa; Aguilar, Helena; Aguilar, Helena; Cufí, Sílvia; Cufí, Sílvia; Oliveras, Glòria; Oliveras, Glòria; Turrado, Carlos; Turrado, Carlos; Ortega Gutiérrez, Silvia; Ortega Gutiérrez, Silvia; Benhamú, Bellinda; Benhamú, Bellinda; López-Rodríguez, María Luz; López-Rodríguez, María Luz; Urruticoechea, Ander; Urruticoechea, Ander; Colomer, Ramon; Colomer, Ramon

New strategies in the modulation of fatty acid oxidation as a treatment for obesity (Publication date: 2013-11-07)

Herrero Rodríguez, Laura; Mera Nanín, Paula; Orellana Gavaldà, Josep Maria; Gurunathan, Chandrashekaran; Malandrino, Maria Ida; Mir, Joan Francesc; Makowski, Kamil; Pozo, Macarena; Arasa, Maria del Mar; Ariza Piquer, Xavier; Asins Muñoz, Guillermina; García Gómez, Jordi; García Hegardt, Fausto; Serra i Cucurull, Dolors

Clinical and therapeutic relevance of the metabolic oncogene fatty acid synthase in HER2+ breast cancer.

Corominas-Faja, Bruna; Vellon, Luciano; Cuyàs, Elisabet; Buxó, Maria; Martin-Castillo, Begoña; Serra i Cucurull, Dolors; García Gómez, Jordi; Menendez, Javier A.; Lupu, Ruth

Accesibility | Legal note | Cookies Policy

Coordination

Supporters