dc.contributor.author |
Valle Delgado, Juan José |
dc.contributor.author |
Fernàndez Busquets, Xavier |
dc.date |
2016-12-22T11:05:44Z |
dc.date |
2017-10-18T22:01:25Z |
dc.date |
2016-10-18 |
dc.date |
2016-12-21T19:00:25Z |
dc.identifier.citation |
1746-0913 |
dc.identifier.uri |
http://hdl.handle.net/2445/105108 |
dc.format |
10 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Future Medicine |
dc.relation |
Versió postprint del document publicat a:
http://dx.doi.org/10.2217/fmb-2016-0139 |
dc.relation |
Future Microbiology, 2016, vol. 11, num. 11, p. 1379-1382 |
dc.relation |
http://dx.doi.org/10.2217/fmb-2016-0139 |
dc.rights |
(c) Future Medicine, 2016 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Malària |
dc.subject |
Diagnòstic |
dc.subject |
Malaria |
dc.subject |
Diagnosis |
dc.title |
Rapid diagnostic tests for malaria: past, present and future |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.description.abstract |
Prompt and accurate diagnosis of malaria is part of an effective disease management (1)
,
because if not treated malaria can quickly become life-threatening, whereas false
positives increase treatment costs and drug-induced resistance, giving a wrong idea of
therapeutic efficacy. Since the symptoms of malaria are nonspecific, the observation of
clinical features alone might not be enough and should be confirmed with a
parasitological analysis. Microscopic examination of Giemsa-stained thin and/or thick
blood smears remains the conventional approach for diagnosis (2). The sensitivity of this
relatively inexpensive method is excellent, allowing the detection of as few as 5
parasites per µL of blood, and permitting also the determination of the infecting species
and of the developmental stage of circulating parasites. In addition, smears provide a
permanent record for quality assessment of the diagnosis. However, microscopy
requires considerable expertise learned through extended training, the procedure is
labor-intensive and time-consuming, and the variability in stains and in techniques used
to collect and process blood affects slide interpretation (3). Finally, routine clinical
microscopy cannot reliably detect very low parasitemias (<5 parasites/µL) or
sequestered parasites, and mixed infections are often missed, especially when
Plasmodium malariae and Plasmodium ovale are present, as their densities are often
low relative to Plasmodium falciparum ( |