dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Baena-Fustegueras, Juan Antonio |
dc.contributor.author |
Ferrer, Roser |
dc.contributor.author |
Lecube, Albert |
dc.contributor.author |
Ricart i Jané, David |
dc.contributor.author |
Rossell, Joana |
dc.contributor.author |
Peinado Onsurbe, Julia |
dc.date |
2017-05-18T14:30:38Z |
dc.date |
2017-05-18T14:30:38Z |
dc.date |
2017-02-16 |
dc.date |
2017-05-18T14:30:38Z |
dc.identifier.citation |
2376-0494 |
dc.identifier.citation |
668049 |
dc.identifier.uri |
http://hdl.handle.net/2445/111244 |
dc.format |
11 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Ommega Publishers |
dc.relation |
Reproducció del document publicat a: https://doi.org/10.15436/2376-0494.17.1333 |
dc.relation |
Journal of Diabetes and Obesity , 2017, vol. 4, num. 2, p. 1-11 |
dc.relation |
https://doi.org/10.15436/2376-0494.17.1333 |
dc.rights |
cc-by (c) Baena-Fustegueras, Juan Antonio et al., 2017 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
http://creativecommons.org/licenses/by/3.0/es |
dc.subject |
Obesitat mòrbida |
dc.subject |
Lipoproteïnes |
dc.subject |
Lipases |
dc.subject |
Morbid obesity |
dc.subject |
Lipoproteins |
dc.subject |
Lipase |
dc.title |
Rapid perioperative changes in the quantitative properties of plasma lipases and lipoproteins in morbidly obese surgical patients' |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Background: The impact of bariatric surgery on abnormalities in blood lipids and lipoprotein metabolism during the perioperative period has been poorly studied. Objective: We studied the impact of bariatric surgery on the composition and quantitative properties of lipoproteins and the activity of lipases in the plasma of perioperative morbidly obese patients. Methods: We examined the plasma lipoproteins and lipolytic activities of 34 morbidly obesepatients one month before surgery (OB), pre-anaesthesia (-S), post-anaesthesia ( S), and one day and one month after open Roux-en-Y gastric bypass (RYGB) surgery. Results: Surgical injury induced acute stress, as evidenced by transitory hyperglycaemia and elevated plasma levels of stress hormones. Lipid profiles revealed a significant reduction during surgery and the day after in the plasma levels of total cholesterol (p < 0.0001), which was mainly due to a decrease in low-density lipoprotein cholesterol (cLDL) and was confirmed with a significant reduction in the plasma levels of LDL (approximately 26% reduction). Significant (p < 0.0001) changes were detected in the plasma levels of high-density lipoprotein cholesterol (cHDL) as well as a significant decrease (approximately 19% reduction) in the plasma levels of HDL. A significant (p < 0.0001) rise was noted in the plasma levels of both Lipoprotein Lipase (LPL) (approximately 2.6-fold increase) and hepatic lipase (HL) (approximately 2.2-fold increase) on the day after surgery, occurring simultaneously with the maximum increase in C-reactive protein (CRP) and a day after the peak values for non-esterified fatty acid (NEFA), adrenocorticotropin hormone (ACTH), cortisol and glucose. Conclusion: The present study reveals unreported quantitative perioperative changes in plasma lipases and lipoproteins and related metabolic determinants that may contribute to the adaptive metabolic response to RYGB-induced stress. |