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Title:	Evidence of an efflux pump in Serratia marcescens
Author:	Berlanga Herranz, Mercedes; Vázquez, J. L.; Borrell Hernández, Jordi; Montero Barrientos, Ma. Teresa; Viñas, Miquel
Other authors:	Universitat de Barcelona
Abstract:	Spontaneous mutants resistant to fluoroquinolones were obtained by exposing Serratia marcescens NIMA (wild-type strain) to increasing concentrations of ciprofloxacin both in liquid and on solid media. Frequencies of mutation ranged from 10-7 to 10-9. Active expulsion of antibiotic was explored as a possible mechanism of resistance in mutants as well as changes in topoisomerase target genes. The role of extrusion mechanisms in determining the emergence of multidrug-resistant bacteria was also examined. Mutants resistant to high concentrations of fluoroquinolones had a single mutation in their gyrA QRDR sequences, whereas the moderate resistance in the rest of mutants was due to extrusion of the drug
Subject(s):	-Resistència als medicaments -Antibiòtics -Serratia marcescens -Medicaments antibacterians -Drug resistance -Antibiotics -Serratia marcescens
Rights:	(c) Mary Ann Liebert, Inc., 2000
Document type:	Article Article - Published version
Published by:	Mary Ann Liebert, Inc.
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