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Título:	Prevalent sequences in the Human Genome Can Form Mini i-Motif Structures at Physiological pH
Autor/a:	Mir Morro, Bartomeu; Serrano, Israel; Buitrago, Diana; Orozco López, Modesto; Escaja Sánchez, Nuria; González, Carlos
Otros autores:	Universitat de Barcelona
Abstract:	We report here the solution structure of several repetitive DNA sequences containing d(TCGTTCCGT) and related repeats. At physiological pH, these sequences fold into i-motif like quadruplexes in which every two repeats a globular structure is stabilized by two hemiprotonated C:C+ base pairs, flanked by two minor groove tetrads resulting from the association of G:C or G:T base pairs. The interaction between the minor groove tetrads and the nearby C:C+ base pairs affords a strong stabilization, which results in effective pHT values above 7.5. Longer sequences with more than two repeats are able to fold in tandem, forming a rosary bead-like structure. Bioinformatics analysis shows that these sequences are prevalent in the human genome, and are present in development-related genes.
Materia(s):	-Oligonucleòtids -Cromosomes humans -Genètica humana -Oligonucleotides -Human chromosomes -Human genetics
Derechos:	(c) American Chemical Society , 2017
Tipo de documento:	Artículo Artículo - Versión aceptada
Editor:	American Chemical Society
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