Ni-catalyzed Mild Chemo-, Regio- and Diastereoselective Bond- Formation via Proximal C–C Cleavage of Benzocyclobutenones

Abstract

<p> The first catalytic intermolecular proximal C1<img alt="[BOND]" src="http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif" />C2 cleavage of benzocyclobutenones (BCB) without prior carbonyl activation or employing noble metals has been developed. This protocol operates at room temperature and is characterized by an exquisite chemo-, regio- and diastereoselectivity profile, constituting a unique platform for preparing an array of elusive carbocyclic skeletons.</p>