dc.contributor.author
Lao, Joan R.
dc.contributor.author
Fernández-Pérez, Hector
dc.contributor.author
Vidal-Ferran, Anton
dc.date.accessioned
2018-01-15T16:04:57Z
dc.date.accessioned
2018-02-15T10:28:29Z
dc.date.accessioned
2024-04-23T10:31:43Z
dc.date.available
2018-01-15T16:04:57Z
dc.date.available
2018-02-15T10:28:29Z
dc.date.available
2024-04-23T10:31:43Z
dc.identifier.uri
http://hdl.handle.net/2072/305852
dc.description.abstract
<div> <p> Enantiopure sulfoxides are valuable precursors of organosulfur compounds with a broad application in organic and pharmaceutical chemistry. An unprecedented strategy for obtaining highly enantioenriched sulfoxides based on a hydrogenative kinetic resolution using Rh-complexes of phosphine-phosphites ligands as catalysts is reported. After optimization, highly efficient conditions for the kinetic resolution of racemic sulfoxides have been identified. This methodology has been applied to a set of racemic aralkyl or aryl vinyl sulfoxides and allowed the isolation of both recovered and reduced product in excellent yields and enantioselectivities (up to 99% and 97% ee, respectively; 16 examples).</p> </div> <p> </p>
dc.publisher
American Chemical Society
dc.relation
Ministerio de Economía y Competitividad
dc.relation
ICIQ Foundation
dc.relation
Proyectos de I+D
dc.relation
Severo Ochoa Excellence Accreditation 2014-2018
dc.relation.ispartof
Org. Lett.
dc.rights
© 2015 American Chemical Society
dc.title
Hydrogenative Kinetic Resolution of Vinyl Sulfoxides
dc.type
info:eu-repo/semantics/article
dc.relation.projectID
CTQ2014-60256-P
dc.relation.projectID
SEV-2013-0319
dc.identifier.doi
https://doi.org/10.1021/acs.orglett.5b02139
dc.rights.accessLevel
info:eu-repo/semantics/openAccess
