dc.contributor.author |
Pastor-Barriuso, Roberto |
dc.contributor.author |
Fernandez, Mariana F. |
dc.contributor.author |
Castaño Vinyals, Gemma |
dc.contributor.author |
Whelan, Denis |
dc.contributor.author |
Pérez-Gómez, Beatriz |
dc.contributor.author |
Llorca, Javier |
dc.contributor.author |
Villanueva Belmonte, Cristina |
dc.contributor.author |
Guevara, Marcela |
dc.contributor.author |
Molina-Molina, José Manuel |
dc.contributor.author |
Artacho-Cordón, Francisco |
dc.contributor.author |
Barriuso-Lapresa, Laura |
dc.contributor.author |
Tusquets Trias de Bes, Ignacio |
dc.contributor.author |
Dierssen Sotos, Trinidad |
dc.contributor.author |
Aragonés, Núria |
dc.contributor.author |
Olea, Nicolás |
dc.contributor.author |
Kogevinas, Manolis |
dc.contributor.author |
Pollan, Marina |
dc.date |
2016 |
dc.identifier.citation |
Pastor-Barriuso R, Fernández MF, Castaño-Vinyals G, Whelan D, Pérez-Gómez B, Llorca J. et al. Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain. Environ Health Perspect. 2016 Oct;124(10):1575-1582. http://dx.doi.org/10.1289/EHP157 |
dc.identifier.citation |
0091-6765 |
dc.identifier.citation |
http://dx.doi.org/10.1289/EHP157 |
dc.identifier.uri |
http://hdl.handle.net/10230/27414 |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
National Institute of Environmental Health Sciences |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.rights |
Reproduced from Environmental Health Perspectives http://dx.doi.org/10.1289/EHP157 |
dc.subject |
Mama -- Càncer |
dc.subject |
Estrògens -- Toxicologia |
dc.title |
Total effective xenoestrogen burden in serum samples and risk for breast cancer in a population-based multicase-control study in Spain. |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
BACKGROUND: Most studies on endocrine-disrupting chemicals and breast cancer have focused on single compounds and have produced inconclusive findings. OBJECTIVES: We assessed the combined estrogenic effects of mixtures of xenoestrogens in serum and their relationship to breast cancer risk. METHODS: A total of 186 incident pretreatment breast cancer cases and 196 frequency-matched controls were randomly sampled from a large population-based multicase-control study in Spain. The total effective xenoestrogen burden attributable to organohalogenated xenoestrogens (TEXB-α) and endogenous hormones and more polar xenoestrogens (TEXB-β) was determined in serum samples using high-performance liquid chromatography and E-Screen bioassay. Odds ratios for breast cancer comparing tertiles of serum TEXB-α and TEXB-β were estimated using logistic models, and smooth risk trends were obtained using spline models. RESULTS: Cases had higher geometric mean TEXB-α and TEXB-β levels (8.32 and 9.94 Eeq pM/mL, respectively) than controls (2.99 and 5.96 Eeq pM/mL, respectively). The fully adjusted odds ratios for breast cancer (95% confidence intervals) comparing the second and third tertiles of TEXB-α with the first tertile were 1.77 (0.76, 4.10) and 3.45 (1.50, 7.97), respectively, and those for TEXB-β were 2.35 (1.10, 5.03) and 4.01 (1.88, 8.56), respectively. A steady increase in risk was evident across all detected TEXB-α levels and a sigmoidal trend was observed for TEXB-β. Individual xenoestrogens showed weak and opposing associations with breast cancer risk. CONCLUSIONS: This is the first study to show a strong positive association between serum total xenoestrogen burden and breast cancer risk, highlighting the importance of evaluating xenoestrogen mixtures, rather than single compounds, when studying hormone-related cancers. |
dc.description.abstract |
This study was partially supported by Acción Transversal del Cancer, approved by the Spanish Ministry Council on 11 October 2007; Carlos III Institute of Health (grants PI08/1770, PI09/00773- Cantabria, PI11/00610, PI12/00265, PI12/00488, PI12/00715, and PI12/01270); and Fundación Marqués de Valdecilla (grant API 10/09). Biological samples were stored at biobanks supported by the Carlos III Institute of Health and the European Regional Development Fund (MAR Biobank RD09/0076/00036 and ISCIII Biobank RD09/0076/00108). |