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Título:	Unexpected genomic variability in clinical and environmental strains of the pathogenic yeast Candida parapsilosis
Autor/a:	Pryszcz, Leszek Piotr, 1985-; Németh, Tibor; Gácser, Attila; Gabaldón Estevan, Juan Antonio, 1973-
Abstract:	Invasive candidiasis is the most commonly reported invasive fungal infection worldwide. Although Candida albicans remains the main cause, the incidence of emerging Candida species, such as C. parapsilosis is increasing. It has been postulated that C. parapsilosis clinical isolates result from a recent global expansion of a virulent clone. However, the availability of a single genome for this species has so far prevented testing this hypothesis at genomic scales. We present here the sequence of three additional strains from clinical and environmental samples. Our analyses reveal unexpected patterns of genomic variation, shared among distant strains, that argue against the clonal expansion hypothesis. All strains carry independent expansions involving an arsenite transporter homolog, pointing to the existence of directional selection in the environment, and independent origins of the two clinical isolates. Furthermore, we report the first evidence for the existence of recombination in this species. Altogether, our results shed new light onto the dynamics of genome evolution in C. parapsilosis.
Abstract:	This work was supported by the La Caixa-CRG International Fellowship Program to L.P., the TAMOP 4.2.4. A/2-11-1-2012-001 “National Excellence Program” to T.N., and was supported in part by OTKA NF 84006, NN00374 (ERA-Net/nPathoGenomics Program), EMBO Installation Grant and by the Janos Bolyai Fellowship of the Hungarian Academy of Sciences to A.G. T.G. group research is funded in part by a grant from the Spanish Ministry of Economy and Competitiveness (BIO2012-37161), a grant from the Qatar National Research Fund grant (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union’s Seventh Framework Programme (FP/2007-2013)/ERC (grant agreement no. ERC-/n2012-StG-310325)
Materia(s):	-Genòmica -Càndida
Derechos:	© 2013 Leszek P. Pryszcz et al. This is an Open Acces article distributed under a Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Oxford University Press
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