Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells

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dc.contributor.author	Izaguirre, Victor
dc.contributor.author	Fernández-Fernández, José Manuel, 1967-
dc.contributor.author	Ceña, Valentin
dc.contributor.author	González García, Carmen
dc.date	1997
dc.identifier.citation	Izaguirre V, Fernández-Fernández JM, Ceña V, González-García C. Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells. FEBS letters. 1997; 418(1-2): 39-42. DOI 10.1016/S0014-5793(97)01343-4
dc.identifier.citation	0014-5793
dc.identifier.citation	http://dx.doi.org/10.1016/S0014-5793(97)01343-4
dc.identifier.uri	http://hdl.handle.net/10230/25631
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation	FEBS letters. 1997; 418(1-2): 39-42
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	© Elsevier This is the published version of an article http://dx.doi.org/10.1016/S0014-5793(97)01343-4 that appeared in the journal Developmental cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license
dc.subject	Nicotina
dc.subject	Nicotine
dc.subject	ATP secretion
dc.subject	Chromaffin cell
dc.subject	Imipramine
dc.subject	Desipramine
dc.subject	Calcium channel
dc.title	Tricyclic antidepressants block cholinergic nicotinic receptors and ATP secretion in bovine chromaffin cells
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Nicotine-induced ATP secretion from chromaffin cells was blocked by imipramine and desipramine. This blocking action took place on both, fast and slow, components of ATP secretion. Exposure of chromaffin cells to nicotine (10 microM) for 4 s induced an inward current of about -155 pA. Imipramine and desipramine blocked, in a concentration-dependent manner, both peak inward current and total charge influx in response to nicotine. In addition, imipramine and desipramine partially (40%) blocked depolarization-induced ATP secretion and Ca2+ currents evoked by high K+. This suggests that tricyclic antidepressants block nicotine-induced ATP secretion by acting on two targets: one is the nicotinic receptor itself and the second one are voltage-dependent Ca2+ channels.
dc.description.abstract	This work has been supported in part by grants from Fondo de Investigaciones Sanitarias (95/1655) to C.G.G.; from DGICYT (PM92-0112), Comision Interministerial de Ciencia y Tecnologia, Plan Nacional de Salud (SAF96-0169) and Fundacion Navarro-Tripodi to V.C.

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