Title:
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Synthesis of Rumphellaone A and Hushinone by a Gold-Catalyzed [2 + 2] Cycloaddition
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Author:
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Ranieri, Beatrice; Obradors, Carla; Mato, Mauro; Echavarren, Antonio M.
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Abstract:
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The enantioselective total synthesis of rumphellaone A has been accomplished in 12 steps via a diastereoselective gold(I)-catalyzed [2 + 2] macrocyclization of a 1,10-enyne as the key step to build the cyclobutene moiety. This concise approach has also led to the total synthesis of husinone. |
Publication date:
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2016-05-14 |
Subject(s):
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Quimica |
Rights:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Pages:
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1614 p. |
Document type:
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Article Article - Draft |
DOI:
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10.1021/acs.orglett.6b00473
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