Title:
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Reward learning requires activity of matrix metalloproteinase-9 in the central amygdala
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Author:
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Knapska, Ewelina; Lioudyno, Victoria; Kiryk, Anna; Mikosz, Marta; Górkiewicz, Tomasz; Michaluk, Piotr; Gawlak, Maciej; Chaturvedi, Mayank; Mochol, Gabriela; Balcerzyk, Marcin; Wojcik, Daniel K.; Wilczynski, Grzegorz M.; Kaczmarek, Leszek
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Abstract:
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Learning how to avoid danger and pursue reward depends on negative emotions motivating aversive learning and positive emotions
motivating appetitive learning. The amygdala is a key component of the brain emotional system; however, an understanding of how
various emotions are differentially processed in the amygdala has yet to be achieved.Wereport that matrix metalloproteinase-9 (MMP-9,
extracellularly operating enzyme) in the central nucleus of the amygdala (CeA) is crucial for appetitive, but not for aversive, learning in
mice. The knock-out of MMP-9 impairs appetitively motivated conditioning, but not an aversive one. MMP-9 is present at the excitatory
synapses in the CeA with its activity greatly enhanced after the appetitive training. Finally, blocking extracellular MMP-9 activity with its
inhibitor TIMP-1 provides evidence that local MMP-9 activity in the CeA is crucial for the appetitive, but not for aversive, learning. |
Abstract:
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This work was supported in part by COST Action Grant BM0901, Polish Ministry of Science and Higher Education
(E.K. and L.K.), andTEAMproject from the Foundation for Polish Science (L.K.). E.K. was supported by the Foundation
for Polish Science through itsHOMINGprogram. |
Rights:
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© The Authors. Published by the Society for Neuroscience http://www.jneurosci.org/content/33/36/14591. This article is published under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/
http://creativecommons.org/licenses/by-nc-sa/3.0/ |
Document type:
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Article Article - Published version |
Published by:
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Society for Neuroscience
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