dc.contributor.author |
Maestre, Lourdes |
dc.contributor.author |
Dorel, Ruth |
dc.contributor.author |
Pablo, Óscar |
dc.contributor.author |
Escofet, Imma |
dc.contributor.author |
Sameera, W. M. C. |
dc.contributor.author |
Álvarez, Eleuterio |
dc.contributor.author |
Maseras, Feliu |
dc.contributor.author |
Díaz-Requejo, M. Mar |
dc.contributor.author |
Echavarren, Antonio M. |
dc.contributor.author |
Peŕez, Pedro J. |
dc.date.accessioned |
2018-11-08T16:19:09Z |
dc.date.available |
2018-11-08T16:19:09Z |
dc.date.issued |
2017-01-18 |
dc.identifier.uri |
http://hdl.handle.net/2072/335521 |
dc.format.extent |
2216 p. |
dc.language.iso |
eng |
dc.rights |
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source |
RECERCAT (Dipòsit de la Recerca de Catalunya) |
dc.subject.other |
54 |
dc.title |
Functional-Group-Tolerant, Silver-Catalyzed N−N Bond Formation by Nitrene Transfer to Amines |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.embargo.terms |
12 mesos |
dc.relation.projectID |
info:eu-repo/grantAgreement/EC/FP7/321066 |
dc.identifier.doi |
10.1021/jacs.6b08219 |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
Silver(I) promotes the highly chemoselective N-amidation of tertiary amines under catalytic conditions to form aminimides by nitrene transfer from PhINTs. Remarkably, this transformation proceeds in a selective manner in the presence of olefins and other functional groups without formation of the commonly observed aziridines or C−H insertion products. The methodology can be applied not only to rather simple tertiary amines but also to complex natural molecules such as brucine or quinine, where the products derived from N−N bond formation were exclusively formed. Theoretical mechanistic studies have shown that this selective N-amidation reaction proceeds through triplet silver nitrenes. |