Title:
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Do nutritional supplements have a role in age macular degeneration prevention?
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Author:
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Pinazo Durán, Maria D.; Gómez Ulla, Francisco; Arias Barquet, Lluís; Araiz, Javier; Casaroli Marano, Ricardo Pedro; Gallego Pinazo, Roberto; García Medina, Jose J.; López Gálvez, María Isabel; Manzanas, Lucía; Salas, Anna; Zapata, Miguel; Diaz Llopis, Manuel; García Layana, Alfredo
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Abstract:
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Purpose. To review the proposed pathogenic mechanisms of age macular degeneration (AMD), as well as the role of antioxidants (AOX) and omega-3 fatty acids (omega-3) supplements in AMD prevention. Materials and Methods. Current knowledge on the cellular/molecular mechanisms of AMD and the epidemiologic/experimental studies on the effects of AOX and omega-3 were addressed all together with the scientific evidence and the personal opinion of professionals involved in the Retina Group of the OFTARED (Spain). Results. High dietary intakes of omega-3 and macular pigments lutein/zeaxanthin are associated with lower risk of prevalence and incidence in AMD. The Age-Related Eye Disease study (AREDS) showed a beneficial effect of high doses of vitamins C, E, beta-carotene, and zinc/copper in reducing the rate of progression to advanced AMD in patients with intermediate AMD or with one-sided late AMD. The AREDS-2 study has shown that lutein and zeaxanthin may substitute beta-carotene because of its potential relationship with increased lung cancer incidence. Conclusion. Research has proved that elder people with poor diets, especially with low AOX and omega-3 micronutrients intake and subsequently having low plasmatic levels, are more prone to developing AMD. Micronutrient supplementation enhances antioxidant defense and healthy eyes and might prevent/retard/modify AMD. |
Subject(s):
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-Malalties de la retina -Suplements nutritius -Retinal diseases -Dietary supplements |
Rights:
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cc-by (c) Pinazo Durán, Maria D. et al., 2014
http://creativecommons.org/licenses/by/3.0/es |
Document type:
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Article Article - Published version |
Published by:
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Hindawi
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