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Title:	Absence of canonical active chromatin marks in developmentally regulated genes
Author:	Pérez-Lluch, Sílvia; Blanco García, Enrique; Tilgner, Hagen; Curado, Joao; Ruiz-Romero, Marina; Corominas, Montserrat (Corominas Guiu); Guigó Serra, Roderic
Other authors:	Universitat de Barcelona
Abstract:	The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally regulated during fly and worm development occurs in the absence of canonically active histone modifications. Conversely, strong chromatin marking is related to transcriptional and post-transcriptional stability, an association that we also observe in mammals. Our results support a model in which chromatin marking is associated with the stable production of RNA, whereas unmarked chromatin would permit rapid gene activation and deactivation during development. In the latter case, regulation by transcription factors would have a comparatively more important regulatory role than chromatin marks.
Subject(s):	-Expressió gènica -Histones -Transcripció genètica -Gene expression -Histones -Genetic transcription
Rights:	(c) Pérez-Lluch, Sílvia et al., 2015
Document type:	Article Article - Accepted version
Published by:	Nature Publishing Group
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