Title:
|
A multifunctional toolkit for target-directed cancer therapy
|
Author:
|
Terrazas Martínez, Montserrat; Sánchez, Dani; Battistini, Federica; Villegas, Núria; Brun-Heath, Isabelle; Orozco López, Modesto
|
Abstract:
|
Here we present 2shRNA, a shRNA-based nanobinder, which can simultaneously attack two therapeutic targets involved in drug resistance pathways and can additionally bind accessory molecules such as cell targeting peptides or fluorophores. We create 2shRNAs designed to specifically kill HER2+ breast cancer cells in the absence of a transfecting agent. |
Subject(s):
|
-Càncer de mama -Cèl·lules canceroses -Breast cancer -Cancer cells |
Rights:
|
(c) Terrazas Martínez et al., 2018
|
Document type:
|
Article |
Published by:
|
Royal Society of Chemistry
|
Share:
|
|