dc.contributor.author |
Filippini, Gicomo |
dc.contributor.author |
Silvi, Mattia |
dc.contributor.author |
Melchiorre, Paolo |
dc.date.accessioned |
2019-02-27T15:43:45Z |
dc.date.available |
2019-02-27T15:43:45Z |
dc.date.issued |
2017-03-21 |
dc.identifier.uri |
http://hdl.handle.net/2072/350688 |
dc.format.extent |
4447 p. |
dc.language.iso |
eng |
dc.rights |
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source |
RECERCAT (Dipòsit de la Recerca de Catalunya) |
dc.subject.other |
54 |
dc.title |
Enantioselective Formal a-Methylation and a-Benzylation of Aldehydes by Means of Photo-organocatalysis |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.embargo.terms |
12 mesos |
dc.relation.projectID |
info:eu-repo/grantAgreement/EC/FP7/681840 |
dc.identifier.doi |
10.1002/anie.201612045 |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
Detailed herein is the photochemical organocatalytic enantioselective a-alkylation of aldehydes with (phenylsulfo- nyl)alkyl iodides. The chemistry relies on the direct photo- excitation of enamines to trigger the formation of reactive carbon-centered radicals from iodosulfones, while the ground- state chiral enamines provide effective stereochemical control over the radical trapping process. The phenylsulfonyl moiety, acting as a redox auxiliary group, facilitates the generation of radicals. In addition, it can eventually be removed under mild reducing conditions to reveal methyl and benzyl groups. |