Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling

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dc.contributor.author	Jobst, Beatrice M.
dc.contributor.author	Hindriks, Rikkert
dc.contributor.author	Laufs, Helmut
dc.contributor.author	Tagliazucchi, Enzo
dc.contributor.author	Hahn, Gerald
dc.contributor.author	Ponce-Alvarez, Adrián
dc.contributor.author	Stevner, Angus B. A.
dc.contributor.author	Kringelbach, Morten L.
dc.contributor.author	Deco, Gustavo
dc.date	2017
dc.identifier.citation	Jobst BM, Hindriks R, Laufs H, Tagliazucchi E, Hahn G, Ponce-Alvarez A, Stevner ABA, Kringelbach ML, Deco G. Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling. Sci Rep. 2017 Jul 5;7:4634. DOI: 10.1038/s41598-017-04522-x
dc.identifier.citation	2045-2322
dc.identifier.citation	https://dx.doi.org/10.1038/s41598-017-04522-x
dc.identifier.uri	http://hdl.handle.net/10230/37093
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Nature Research
dc.relation	Scientific Reports. 2017 Jul 5;7:4634.
dc.relation	info:eu-repo/grantAgreement/EC/FP7/295129
dc.relation	info:eu-repo/grantAgreement/EC/H2020/720270
dc.relation	info:eu-repo/grantAgreement/EC/H2020/661583
dc.relation	info:eu-repo/grantAgreement/ES/1PE/PSI2013-42091
dc.relation	info:eu-repo/grantAgreement/ES/1PE/PSI2016-75688-P
dc.relation	info:eu-repo/grantAgreement/ES/1PE/PCIN-2013-026
dc.relation	info:eu-repo/grantAgreement/ES/1PE/IJCI-2014-21066
dc.relation	info:eu-repo/grantAgreement/EC/FP7/615539
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	© This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
dc.rights	http://creativecommons.org/licenses/by/4.0/
dc.subject	Computational neuroscience
dc.subject	Computational science
dc.title	Increased stability and breakdown of brain effective connectivity during slow-wave sleep: mechanistic insights from whole-brain computational modelling
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Recent research has found that the human sleep cycle is characterised by changes in spatiotemporal patterns of brain activity. Yet, we are still missing a mechanistic explanation of the local neuronal dynamics underlying these changes. We used whole-brain computational modelling to study the differences in global brain functional connectivity and synchrony of fMRI activity in healthy humans during wakefulness and slow-wave sleep. We applied a whole-brain model based on the normal form of a supercritical Hopf bifurcation and studied the dynamical changes when adapting the bifurcation parameter for all brain nodes to best match wakefulness and slow-wave sleep. Furthermore, we analysed differences in effective connectivity between the two states. In addition to significant changes in functional connectivity, synchrony and metastability, this analysis revealed a significant shift of the global dynamic working point of brain dynamics, from the edge of the transition between damped to sustained oscillations during wakefulness, to a stable focus during slow-wave sleep. Moreover, we identified a significant global decrease in effective interactions during slow-wave sleep. These results suggest a mechanism for the empirical functional changes observed during slow-wave sleep, namely a global shift of the brain’s dynamic working point leading to increased stability and decreased effective connectivity.
dc.description.abstract	BMJ, RH, GH, APA and GD were funded by the European Research Council (ERC) Advanced Grant DYSTRUCTURE (n. 295129), European Union’s Horizon 2020 research and innovation programme under grant agreement No. 720270 (HBP SGA1) and No. 661583 (CONSBRAIN), by the Programa Estatal de Investigación Cientifica y Tecnica de Excelencia MINECO (PSI2013-42091, PSI2016-75688-P (AEI/FEDER, EU) and PCIN-2013-026), Juan de la Cierva fellowship (IJCI-2014-21066) and by the Catalan Agency for Management of University and Research Grants, AGAUR (2014SGR856). ET and HL were supported by the Bundesministerium für Bildung und Forschung (grantnumber 01 EV 0703) and the LOEWE Neuronale Koordination Forschungsschwerpunkt Frankfurt (NeFF). ET was further funded by a postdoctoral grant of the AXA foundation. MLK was supported by the ERC Consolidator Grant CAREGIVING (n. 615539).

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