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Title:	Cooperative force generation of KIF1A Brownian motors
Author:	Oriola Santandreu, David; Casademunt i Viader, Jaume
Other authors:	Universitat de Barcelona
Abstract:	KIF1A is a kinesin motor protein that can work processively in a monomeric (single-headed) form by using a noise-driven ratchet mechanism. Here, we show that the combination of a passive diffusive state and finite-time kinetics of adenosine triphosphate hydrolysis provides a powerful mechanism of cooperative force generation, implying for instance that ∼ 10 monomeric KIF1As can team up to become ∼ 100 times stronger than a single one. Consequently, we propose that KIF1A could outperform conventional (double-headed) kinesin collectively and thus explain its specificity in axonal trafficking. We elucidate the cooperativity mechanism with a lattice model that includes multiparticle transitions.
Subject(s):	-Proteïnes quinases -Monòmers -Protein kinases -Monomers
Rights:	(c) American Physical Society, 2013
Document type:	Article Article - Published version
Published by:	American Physical Society
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