Metal-Free Synthesis of N-Aryl Amides using Organocatalytic Ring-Opening Aminolysis of Lactones

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Empreu aquest identificador per citar o enllaçar aquest document: http://hdl.handle.net/2072/356181

Títol:	Metal-Free Synthesis of N-Aryl Amides using Organocatalytic Ring-Opening Aminolysis of Lactones
Autor/a:	Guo, Wusheng; Gómez, José Enrique; Martínez-Rodríguez, Luis; Bandeira, Nuno A. G.; Bo, Carles; Kleij, Arjan W.
Abstract:	Catalytic ring-opening of bio-sourced non-strained lactones with aromatic amines can offer a straightforward, 100% atom- economical and sustainable pathway towards relevant N-aryl amide scaffolds. We herein report the first general, metal-free and highly efficient N-aryl amide formation from poorly reactive aromatic amines and non-strained lactones under mild operating conditions using an organic bicyclic guanidine catalyst. This protocol has great application potential as exemplified by the formal syntheses of drug relevant molecules.
Data de publicació:	09-05-2017
Matèries:	54
Drets:	L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/
Pàgines:	1969 p.
Tipus de document:	Article Article - Versió acceptada
DOI:	10.1002/cssc.201700415
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ChemSusChem 2017, 10, 1969-1975 (KLEIJ).pdf	1.307 MB	PDF

Martínez-Rodríguez, Luis; Bandeira, Nuno A. G.; Bo, Carles; Kleij, Arjan W.

Guo, Wusheng; Gónzalez-Fabra, Joan; Bandeira, Nuno A. G.; Bo, Carles; Kleij, Arjan W.

Guo, Wusheng; Gónzalez-Fabra, Joan; Bandeira, Nuno A. G.; Bo, Carles; Kleij, Arjan W.

Cai, Aijie; Guo, Wusheng; Martínez-Rodríguez, Luis; Kleij, Arjan W.

Guo, Wusheng; Martínez-Rodríguez, Luis; Kuniyil, Rositha; Martin, Eddy; Escudero- Adán, Eduardo C.; Maseras, Feliu; Kleij, Arjan W.

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