Títol:
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Palladium-Catalyzed (Z)-Selective Allylation of Nitroalkanes: Access to Highly Functionalized Homoallylic Scaffolds
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Autor/a:
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Cristòfol, Àlex; Escudero-Adán, Eduardo C.; Kleij, Arjan W.
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Abstract:
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Nitroalkanes undergo decarboxylative allylation in the presence of vinyl-substituted cyclic carbonates providing a wide variety of functionalized homoallylated compounds with exquisite stereocontrol. This Pd-mediated procedure features opera- tional simplicity, versatile substrate combinations and also allows for the sequential introduction of different allyl groups in the nitroalkane scaffolds with high levels of stereocontrol through the intermediacy of a (Z)-configured palladacyclic intermediate. As far as we know, the developed protocol is the first general Pd-mediated methodology towards (Z)-configured homoallylic nitroalkanes with attractive functional group diversity. |
Data de publicació:
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15-08-2018 |
Matèries:
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54 |
Drets:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nd/4.0/ |
Pàgines:
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9978 p. |
Tipus de document:
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Article Article - Versió acceptada |
DOI:
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10.1021/acs.joc.8b01372
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