Para acceder a los documentos con el texto completo, por favor, siga el siguiente enlace: http://hdl.handle.net/2445/134067

Título:	Fluoroquinolone resistance in penicillin-resistant streptococcus pneumoniae clones, Spain
Autor/a:	Campa, Adela G. de la; Balsalobre, Luz; Ardanuy Tisaire, María Carmen; Fenoll, Asunción; Pérez Trallero, Emilio; Liñares Louzao, Josefina; Spanish Pneumococcal Infection Study Network
Otros autores:	Universitat de Barcelona
Abstract:	Among 2,882 Streptococcus pneumoniae sent to the Spanish Reference Laboratory during 2002, 75 (2.6%) were ciprofloxacin-resistant. Resistance was associated with older patients (3.9% in adults and 7.2% in patients > or =65 years of age), with isolation from noninvasive sites (4.3% vs. 1.0%), and with penicillin and macrolide resistance. Among 14 low-level resistant (MIC 4-8 microg/mL) strains, 1 had a fluoroquinolone efflux phenotype, and 13 showed single ParC changes. The 61 high-level ciprofloxacin-resistant (MIC > or =16 microg/mL) strains showed either two or three changes at ParC, ParE, and GyrA. Resistance was acquired either by point mutation (70 strains) or by recombination with viridans streptococci (4 strains) at the topoisomerase II genes. Although 36 pulsed-field gel electrophoresis patterns were observed, 5 international multiresistant clones (Spain23F-1, Spain6B-2, Spain9V-3, Spain14-5 and Sweden15A-25) accounted for 35 (46.7%) of the ciprofloxacin-resistant strains. Continuous surveillance is needed to prevent the dissemination of these clones.
Materia(s):	-Resistència als medicaments -Genètica -Quinolones -Farmacologia -Farmacocinètica -Pneumococs -Espanya -Drug resistance -Genetics -Quinolone antibacterial agents -Pharmacology -Pharmacokinetics -Streptococcus pneumonia -Spain
Derechos:	, 2004
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Centers for Disease Control and Prevention
Compartir:

Mostrar el registro completo del ítem