Títol:
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Use of anthropophilic culicid-based xenosurveillance as a proxy
for Plasmodium vivax malaria burden and transmission hotspots
identification
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Autor/a:
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Nascimento, Joabi; Sampaio, Vanderson S.; Karl, Stephan; Kuehn, Andrea; Almeida, Anne; Vitor-Silva, Sheila; Cardoso de Melo, Gisely; Baia da Silva, Djane C.; lopes, Stefanie C. P.; Fé, Nelson F; Pereira Lima, José B.; Barbosa Guerra, Maria G.; Pimenta, Paulo F. P.; Bassat Orellana, Quique; Mueller, Ivo; Lacerda, Marcus Vinícius Guimarães; Monteiro, Wuelton M.
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Abstract:
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Vector-borne diseases account for more than 17% of all
infectious diseases, causing more than one million deaths
annually. Malaria remains one of the most important public
health problems worldwide. These vectors are bloodsucking
insects, which can transmit disease-producing microorganisms
during a blood meal. The contact of culicids with human
populations living in malaria-endemic areas suggests that the
identification of Plasmodium genetic material in the blood
present in the gut of these mosquitoes may be possible. The
process of assessing the blood meal for the presence of
pathogens is termed 'xenosurveillance'. In view of this, the
present work investigated the relationship between the frequency
with which Plasmodium DNA is found in culicids and the frequency
with which individuals are found to be carrying malaria
parasites. A cross-sectional study was performed in a peri-urban
area of Manaus, in the Western Brazilian Amazon, by
simultaneously collecting human blood samples and trapping
culicids from households. A total of 875 individuals were
included in the study and a total of 13,374mosquito specimens
were captured. Malaria prevalence in the study area was 7.7%.
The frequency of households with at least one culicid specimen
carrying Plasmodium DNA was 6.4%. Plasmodium infection incidence
was significantly related to whether any Plasmodium positive
blood-fed culicid was found in the same household [IRR 3.49
(CI95% 1.38-8.84); p = 0.008] and for indoor-collected culicids
[IRR 4.07 (CI95%1.25-13.24); p = 0.020]. Furthermore, the number
of infected people in the house at the time of mosquito
collection was related to whether there were any positive
blood-fed culicid mosquitoes in that household for collection
methods combined [IRR 4.48 (CI95%2.22-9.05); p<0.001] or only
for indoor-collected culicids [IRR 4.88 (CI95%2.01-11.82);
p<0.001]. Our results suggest that xenosurveillance can be
used in endemic tropical regions in order to estimate the
malaria burden and identify transmission foci in areas where
Plasmodium vivax is predominant. |
Matèries:
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-Plasmodium vivax -Malària -Malaria |
Drets:
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cc by (c) Nascimento et al., 2018
http://creativecommons.org/licenses/by/3.0/es/ |
Tipus de document:
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Article Article - Versió publicada |
Publicat per:
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Public Library of Science (PLoS)
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