dc.contributor.author
Cuadros, Sara
dc.contributor.author
Horwitz, Matthew A.
dc.contributor.author
Schweitzer-Chaput, Bertrand
dc.contributor.author
Melchiorre, Paolo
dc.date.accessioned
2019-06-17T12:20:20Z
dc.date.accessioned
2024-04-23T10:19:15Z
dc.date.available
2019-06-17T12:20:20Z
dc.date.available
2024-04-23T10:19:15Z
dc.date.issued
2019-02-18
dc.identifier.uri
https://hdl.handle.net/2072/357528
dc.description.abstract
We report a photoinduced three-component radical process, which couples readily available alkyl chlorides, maleimides, and heteroaromatic fragments to rapidly generate complex chiral products with high diastereocontrol. This method generates radicals via an SN2-based photochemical catalytic mechanism, which is not reliant on the redox properties of the precursors. It therefore grants access to open-shell intermediates from substrates that would be incompatible with or inert to classical radical- generating strategies. The redox-neutral conditions of this process make it tolerant of redox-sensitive substrates and allow the installation of multiple biologically relevant heterocycles within the cascade products.
dc.format.extent
5484 p.
cat
dc.rights
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.source
RECERCAT (Dipòsit de la Recerca de Catalunya)
dc.title
A visible-light mediated three-component radical process using dithiocarbamate anion catalysis
cat
dc.type
info:eu-repo/semantics/article
cat
dc.type
info:eu-repo/semantics/acceptedVersion
cat
dc.relation.projectID
info:eu-repo/grantAgreement/EC/FP7/681840
cat
dc.identifier.doi
https://doi.org/10.1039/c9sc00833k
dc.rights.accessLevel
info:eu-repo/semantics/openAccess
