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Títol:	Systems analysis reveals complex biological processes during virus infection fate decisions
Autor/a:	Argilaguet Marqués, Jordi, 1977-; Pedragosa Marín, Mireia, 1988-; Esteve-Codina, Anna; Riera Domínguez, María Graciela, 1987-; Vidal, Enric; Peligero Cruz, Cristina, 1986-; Casella, Valentina; Andreu Martínez, David; Kaisho, Tsuneyasu; Bocharov, Gennady A.; Ludewig, Burkhard; Heath, Simon; Meyerhans, Andreas
Abstract:	The processes and mechanisms of virus infection fate decisions that are the result of a dynamic virus-immune system interaction with either an efficient effector response and virus elimination or an alleviated immune response and chronic infection are poorly understood. Here, we characterized the host response to acute and chronic lymphocytic choriomeningitis virus (LCMV) infections by gene coexpression network analysis of time-resolved splenic transcriptomes. First, we found an early attenuation of inflammatory monocyte/macrophage prior to the onset of T cell exhaustion, and second, a critical role of the XCL1-XCR1 communication axis during the functional adaptation of the T cell response to the chronic infection state. These findings not only reveal an important feedback mechanism that couples T cell exhaustion with the maintenance of a lower level of effector T cell response but also suggest therapy options to better control virus levels during the chronic infection phase.
Abstract:	This work was supported by a grant from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER Grant No. SAF2016-75505-R (AEI/MINEICO/FEDER, UE), the Russian Science Foundation Grant 18-11-00171, the Uehara Memorial Foundation (to T.K.), Grant-in-Aid for Scientific Research B 17H04088 from the Japan Society for the Promotion of Science (JSPS), (to T.K.), and the grant of the National Bioinformatics Institute (INB), PRB2-ISCIII (PT13/0001/0044 to A.E.-C.).
Drets:	info:eu-repo/semantics/embargoedAccess Published originally by Cold Spring Harbor Laboratory Press at http://dx.doi.org/10.1101/gr.241372.118. Beginning six months from the full-issue publication date, articles are distributed under the Creative Commons Attribution-Non-Commercial 4.0 International License (CC-BY-NC), as described at http://creativecommons.org/licenses/by-nc/4.0/. This license permits non-commercial use, including reproduction, adaptation, and distribution of the article provided the original author and source are credited. http://creativecommons.org/licenses/by-nc/4.0/
Tipus de document:	Article Article - Versió publicada
Publicat per:	Cold Spring Harbor Laboratory Press (CSHL Press)
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