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Title:	Comparison of 2D versus M-mode echocardiography for assessing fetal myocardial wall thickness
Author:	Sepúlveda-Martínez, Alvaro; García-Otero, Laura; Soveral, Iris; Guirado, Laura; Valenzuela-Alcaraz, Brenda; Torres, Ximena; Rodriguez-Lopez, Mérida; Gratacós Solsona, Eduard; Gómez, Olga; Crispi Brillas, Fàtima
Other authors:	Universitat de Barcelona
Abstract:	OBJECTIVE: M-mode and 2D have been proposed for evaluating fetal myocardial thickness. However, studies comparing the performance of both modalities are lacking. We aimed to compare 2D versus M-mode reproducibility for assessing myocardial wall thicknesses. METHODS: A prospective study including 45 healthy fetuses from low-risk pregnancies evaluated between 18 and 41 weeks of gestation. Left and right ventricular free-wall and septal myocardial thicknesses were measured at end-diastole (ED) and end-systole (ES) in transverse 4-chamber view using 2D and M-mode. Intra- and interobserver reproducibility was evaluated by the concordance correlation coefficient (CCC). Both techniques were compared by t-test of the CCC. RESULTS: 2D and M-mode demonstrated excellent and similar intraobserver repeatability, with the best concordance in ES septal thickness (M-mode CCC 0.956 versus 2D-mode CCC 0.914). Interobserver reproducibility demonstrated also a high concordance, optimal in ES left ventricular free wall (M-mode 0.925 versus 2 D 0.855). Comparison of both techniques demonstrated a high concordance in all measurements, except for ED septal thickness with better reproducibility using M-mode (CCC 0.954 versus 0.847, p = .017). CONCLUSIONS: 2D and M-mode can be used in a reproducible manner for measuring fetal myocardial thickness, with a slightly better performance of M-mode for assessing ED septal wall thickness.
Subject(s):	-Ecocardiografia -Cor -Fetus -Estudi de casos -Echocardiography -Heart -Fetus -Case studies
Rights:	(c) Informa UK Ltd., 2018
Document type:	Article Article - Accepted version
Published by:	Informa UK Ltd.
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