dc.contributor |
Universitat de Barcelona |
dc.contributor.author |
Roca Millan, Elisabet |
dc.contributor.author |
González Navarro, Beatriz |
dc.contributor.author |
Sabater Recolons, Ma. del Mar |
dc.contributor.author |
Marí Roig, Antonio |
dc.contributor.author |
Jané Salas, Enric |
dc.contributor.author |
López López, José, 1958- |
dc.date |
2019-11-27T19:21:46Z |
dc.date |
2019-11-27T19:21:46Z |
dc.date |
2018-11-01 |
dc.date |
2019-11-27T19:21:46Z |
dc.identifier.citation |
1698-4447 |
dc.identifier.citation |
683652 |
dc.identifier.uri |
http://hdl.handle.net/2445/145578 |
dc.format |
10 p. |
dc.format |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Medicina Oral SL |
dc.relation |
Reproducció del document publicat a: https://doi.org/10.4317/medoral.22725 |
dc.relation |
Medicina Oral, Patología Oral y Cirugía Bucal, 2018, vol. 23, num. 6, p. 681-690 |
dc.relation |
https://doi.org/10.4317/medoral.22725 |
dc.rights |
(c) Medicina Oral SL, 2018 |
dc.rights |
info:eu-repo/semantics/openAccess |
dc.subject |
Malalties periodontals |
dc.subject |
Malalties cardiovasculars |
dc.subject |
Aterosclerosi |
dc.subject |
Periodontal disease |
dc.subject |
Cardiovascular diseases |
dc.subject |
Atherosclerosis |
dc.title |
Periodontal treatment on patients with cardiovascular disease: systematic review and meta-analysis |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/publishedVersion |
dc.description.abstract |
Background: atherosclerotic cardiovascular disease is the main cause of mortality in developed countries. It is a chronic and systemic inflammatory disease with a multifactorial etiology. Periodontal disease is one of the many factors that contribute to its development. Objective: to analyze the effects of periodontal treatment on cardiovascular risk parameters in patients with atherosclerotic cardiovascular disease. Methods: a systematic research was conducted in the Pubmed/Medline databases for clinical trials published up to and including the year 2017. Results: ten articles were included for analysis. Periodontal treatment reduced C-reactive protein levels (77.8% of clinical trials), tumor necrosis factor-alpha (66.7%), interleukin-6 (100%) and leukocytes (50%). Fibrinogen levels also improved considerably (66.7%). Effects on lipid parameters were more limited, whereby only oxidized low density lipoprotein and very low density lipoprotein cholesterol decreased significantly. Meta-analysis showed a statistically significant decreased in C-reactive protein and leukocytes values when patients were submitted to non-surgical periodontal treatment in contrast to receiving no treatment at all (mean difference 1.199 mg/L, 95% confidence interval: 1.100-1.299, p<0.001; and mean difference 0,79 g/L, 95% confidence interval: 0.717-0.879, p<0.001, respectively). Conclusions: periodontal treatment has a beneficial effect on some of the biochemical parameters considered to represent cardiovascular risk. Further randomized clinical trials are necessary, with longer follow-up periods including regular periodic monitoring, in order to determine the extent of the impact of periodontal treatment. |