Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation

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dc.contributor.author	Coll, Olga
dc.contributor.author	Guitart, Tanit
dc.contributor.author	Villalba, Ana
dc.contributor.author	Papin, Catherine
dc.contributor.author	Simonelig, Martine
dc.contributor.author	Gebauer, Fátima
dc.date	2018
dc.identifier.citation	Coll O, Guitart T, Villalba A, Papin C, Simonelig M, Gebauer F. Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation. RNA. 2018; 24(4):529-539. DOI 10.1261/rna.065417.117
dc.identifier.citation	1355-8382
dc.identifier.citation	http://dx.doi.org/10.1261/rna.065417.117
dc.identifier.uri	http://hdl.handle.net/10230/43101
dc.format	application/pdf
dc.language.iso	eng
dc.publisher	Cold Spring Harbor Laboratory Press (CSHL Press)
dc.relation	RNA. 2018; 24(4):529-539
dc.relation	info:eu-repo/grantAgreement/ES/3PN/BFU2012-37135
dc.relation	info:eu-repo/grantAgreement/ES/1PE/BFU2015-68741
dc.rights	info:eu-repo/semantics/openAccess
dc.rights	© 2018 Coll et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society. This article, published in RNA, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.
dc.rights	http://creativecommons.org/licenses/by/4.0/
dc.subject	Dicer-2
dc.subject	Wispy
dc.subject	Cytoplasmic polyadenylation
dc.subject	Translation
dc.title	Dicer-2 promotes mRNA activation through cytoplasmic polyadenylation
dc.type	info:eu-repo/semantics/article
dc.type	info:eu-repo/semantics/publishedVersion
dc.description.abstract	Cytoplasmic polyadenylation is a widespread mechanism to regulate mRNA translation. In vertebrates, this process requires two sequence elements in target 3' UTRs: the U-rich cytoplasmic polyadenylation element and the AAUAAA hexanucleotide. In Drosophila melanogaster, cytoplasmic polyadenylation of Toll mRNA occurs independently of these canonical elements and requires a machinery that remains to be characterized. Here we identify Dicer-2 as a component of this machinery. Dicer-2, a factor previously involved in RNA interference (RNAi), interacts with the cytoplasmic poly(A) polymerase Wispy. Depletion of Dicer-2 from polyadenylation-competent embryo extracts and analysis of wispy mutants indicate that both factors are necessary for polyadenylation and translation of Toll mRNA. We further identify r2d2 mRNA, encoding a Dicer-2 partner in RNAi, as a Dicer-2 polyadenylation target. Our results uncover a novel function of Dicer-2 in activation of mRNA translation through cytoplasmic polyadenylation.
dc.description.abstract	This work was supported by MINECO and the European Regional Development Fund (ERDF) under BFU2012-37135, BFU2015-68741, and Consolider CSD2009-00080 grants to F.G., and by the CNRS UMR9002, ANR (ANR-2010-BLAN-1201-01 and ANR-15-CE12-0019-01), and FRM (Equipe FRM 2013 DEQ20130326534) to M.S. We acknowledge support of MINECO “Centro de Excelencia Severo Ochoa 2013-2017,” SEV-2012-0208.

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