Title:
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Unified Total Synthesis of Pyrroloazocine Indole Alkaloids Sheds Light on Their Biosynthetic Relationship
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Author:
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Miloserdov, Fedor M.; Kirillova, Mariia S.; Muratore, Michael E.; Echavarren, Antonio M.
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Abstract:
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The total synthesis of seven members of the lapidilectine and
grandilodine family of alkaloids has been accomplished in racemic and
enantiopure form without protection/deprotection of functional groups. The
two key steps, an 8-endo-dig hydroarylation and a 6-exo-trig photoredox
cyclization, were catalyzed using gold. A rationale for the formation of the
cyclopropane ring of the lundurines is also provided. |
Publication date:
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2018-02-12 |
Subject(s):
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54 |
Rights:
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L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Pages:
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5393 p. |
Document type:
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Article Article - Accepted version |
DOI:
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10.1021/jacs.7b13484
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