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Título:	Datasets for the validation of the 'in vivo' siRNA-silencing of CD40 and for the detection of new markers of aterosclerosis progression in ApoE-deficient mice
Autor/a:	Hueso Val, Miguel; Ramon, Laura De; Navarro, Estanislau; Ripoll Llagostera, Èlia; Cruzado, Josep Ma.; Grinyó Boira, Josep M.; Torras Ambròs, Joan
Abstract:	Data presented in this Data in Brief article correspond to the article 'in vivo' silencing of CD40 reduces progression of experimental atherogenesis through a NFκB/miR-125b axis and reveals new potential mediators in the pathogenesis of atherosclerosis' (M. Hueso, L. De Ramon, E. Navarro, E. Ripoll, J.M. Cruzado, J.M. Grinyo, J. Torras, 2016) [1]. Here, we describe the validation of the silencing of CD40 expression with a specific siRNA in ApoE−/− mouse aortas, and its systemic effects on splenic lymphocytic subpopulations as well as on the infiltration of aortic intima by F4/80+, galectin-3+ macrophages or by NF-κB+ cells. We also show the output of a Gene Ontology and TLDA analysis which allowed the detection of potential mediators of atherosclerosis progression. We provide the scientific community with a set of genes whose expression is increased during atherosclerosis progression but downregulated upon CD40 silencing.
Materia(s):	-RNA -Macròfags -Aterosclerosi -Ratolins (Animals de laboratori) -RNA -Macrophages -Atherosclerosis -Mice (Laboratory animals)
Derechos:	cc-by (c) Hueso Val, Miguel et al., 2016 http://creativecommons.org/licenses/by/3.0/es
Tipo de documento:	Artículo Artículo - Versión publicada
Editor:	Elsevier
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