Centres de Recerca de Catalunya (CERCA)
2018-12-05
The nickel-catalyzed synthesis of tetrasubstituted cyclobutenes from alkynes is reported. This transformation is uniquely promoted by the use of a primary aminophosphine, an unusual ligand in nickel catalysis. Mechanistic insights for this new transformation are provided, and postreaction modifications of the cyclobutene products to stereodefined cyclic and acyclic compounds are reported, including the synthesis of epi-truxillic acid.
English
54
17349 p.
CTQ2015- 69136- R
(SEV-2013-0319)
(BES-2015- 072152
R35- GM118133
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