Universitat Autònoma de Barcelona
Breakthroughs in genetics over the last decade have radically advanced our understanding of the etiological basis of Parkinson's disease (PD). Although much research remains to be done, the main genetic causes of this neurodegenerative disorder are now partially unraveled, allowing us to feel more confident that our knowledge about the genetic architecture of PD will continue to increase exponentially. How and when these discoveries will be introduced into general clinical practice, however, remains uncertain. In this review, we provide a general summary of the progress in the genetics of PD and discuss how this knowledge will contribute to the diagnosis and clinical management of patients with, or at risk of this disorder.
Anglès
Genetics; Parkinson's disease; Mendelian genes; Genetic testing; PARK; Clinical genetics; Genetic risk factor
Current Genomics ; Vol. 14 (december 2013), p. 560-567
open access
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