Universitat Autònoma de Barcelona
Altres ajuts: Work in JMP group is supported by the Spanish AIDS network "Red Temática Cooperativa de Investigación en SIDA" (RD06/0006)
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans -infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans -infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans -infection.
English
Ministerio de Ciencia e Innovación SAF2010-21224
PLOS pathogens ; Vol. 10 (july 2014)
open access
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