dc.contributor.author
Izquierdo Useros, Nuria
dc.contributor.author
Lorizate, Maier
dc.contributor.author
McLaren, Paul J.
dc.contributor.author
Telenti, Amalio
dc.contributor.author
Kräusslich, Hans-Georg
dc.contributor.author
Martínez Picado, Francisco Javier
dc.contributor.author
Universitat Autònoma de Barcelona
dc.identifier
https://ddd.uab.cat/record/185070
dc.identifier
urn:10.1371/journal.ppat.1004146
dc.identifier
urn:oai:ddd.uab.cat:185070
dc.identifier
urn:pmid:25033082
dc.identifier
urn:pmcid:PMC4102576
dc.identifier
urn:pmc-uid:4102576
dc.identifier
urn:oai:egreta.uab.cat:publications/e7a8036c-d8d6-4c6c-a330-b56a9ffc36eb
dc.identifier
urn:scopus_id:84905386677
dc.identifier
urn:oai:pubmedcentral.nih.gov:4102576
dc.description.abstract
Altres ajuts: Work in JMP group is supported by the Spanish AIDS network "Red Temática Cooperativa de Investigación en SIDA" (RD06/0006)
dc.description.abstract
Dendritic cells (DCs) are essential in order to combat invading viruses and trigger antiviral responses. Paradoxically, in the case of HIV-1, DCs might contribute to viral pathogenesis through trans -infection, a mechanism that promotes viral capture and transmission to target cells, especially after DC maturation. In this review, we highlight recent evidence identifying sialyllactose-containing gangliosides in the viral membrane and the cellular lectin Siglec-1 as critical determinants for HIV-1 capture and storage by mature DCs and for DC-mediated trans -infection of T cells. In contrast, DC-SIGN, long considered to be the main receptor for DC capture of HIV-1, plays a minor role in mature DC-mediated HIV-1 capture and trans -infection.
dc.format
application/pdf
dc.relation
Ministerio de Ciencia e Innovación SAF2010-21224
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PLOS pathogens ; Vol. 10 (july 2014)
dc.rights
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
dc.rights
https://creativecommons.org/licenses/by/4.0/
dc.title
HIV-1 Capture and Transmission by Dendritic Cells : The Role of Viral Glycolipids and the Cellular Receptor Siglec-1
