Listando IRTA. Institut de Recerca i Tecnologia Agroalimentàries por materia "576"

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Bacterial inclusion bodies are industrially exploitable amyloids

de Marco, Ario; Ferrer-Miralles, Neus; Garcia-Fruitós, Elena; Mitraki, Anna; Peternel, Spela; Rinas, Ursula; Trujillo-Roldán, Mauricio A; Valdez-Cruz, Norma A; Vázquez, Esther; Villaverde, Antonio (2018-10-24)

Understanding the structure, functionalities and biology of functional amyloids is an issue of emerging interest. Inclusion bodies, namely protein clusters formed in recombinant bacteria during protein production processes, ...

Exploring the use of leucine zippers for the generation of a new class of inclusion bodies for pharma and biotechnological applications

Roca-Pinilla, Ramon; Fortuna, Sara; Natalello, Antonino; Sánchez-Chardi, Alejandro; Ami, Diletta; Alomar, Oscar; Garcia-Fruitos, Elena (2020-09-04)

Background Inclusion bodies (IBs) are biologically active protein aggregates forming natural nanoparticles with a high stability and a slow-release behavior. Because of their nature, IBs have been explored to be used as ...

High-Fat Diet-Induced Obesity Increases Brain Mitochondrial Complex I and Lipoxidation-Derived Protein Damage

Berdún, Rebeca; Obis, Èlia; Mota-Martorell, Natàlia; Bassols, Anna; Valent, Daniel; Serrano, José C. E.; Martín-Garí, Meritxell; Rodríguez-Palmero, María; Moreno-Muñoz, José Antonio; Tibau , Joan; Quintanilla, Raquel; Pamplona, Reinald; Portero-Otín, Manuel; Jové, Mariona (2024-01-26)

Obesity is a risk factor for highly prevalent age-related neurodegenerative diseases, the pathogenesis of whichinvolves mitochondrial dysfunction and protein oxidative damage. Lipoxidation, driven by high levels of ...