dc.contributor.author |
Lai, Junshan |
dc.contributor.author |
Sayalero, Sonia |
dc.contributor.author |
Ferrali, Alessandro |
dc.contributor.author |
Osorio-Planes, Laura |
dc.contributor.author |
Bravo, Fernando |
dc.contributor.author |
Rodriguez-Escrich, Carles |
dc.contributor.author |
Pericàs, Miquel A. |
dc.date.accessioned |
2021-08-25T10:49:23Z |
dc.date.available |
2021-08-25T10:49:23Z |
dc.date.issued |
2018-06-07 |
dc.identifier.uri |
http://hdl.handle.net/2072/450556 |
dc.format.extent |
2914 p. |
dc.language.iso |
eng |
dc.rights |
L'accés als continguts d'aquest document queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons:http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source |
RECERCAT (Dipòsit de la Recerca de Catalunya) |
dc.subject.other |
54 |
dc.title |
Immobilization of cis-4-Hydroxydiphenylprolinol Silyl Ethers onto Polystyrene. Application in the Catalytic Enantioselective Synthesis of 5-Hydroxyisoxazolidines in Batch and Flow |
dc.type |
info:eu-repo/semantics/article |
dc.type |
info:eu-repo/semantics/acceptedVersion |
dc.embargo.terms |
12 mesos |
dc.relation.projectID |
CTQ2015-69136-R |
dc.relation.projectID |
SEV- 2013-0319 |
dc.identifier.doi |
https://doi.org/10.1002/adsc.201800572 |
dc.rights.accessLevel |
info:eu-repo/semantics/openAccess |
dc.description.abstract |
A new family of polystyrene-supported cis-4-hydroxydiphenylprolinol silyl ethers has been prepared, and the resulting polymers have been evaluated as organocatalysts to promote the tandem reaction between N-protected hydroxylamines and α,β-unsaturated aldehydes in batch and flow. The new PS-supported catalysts compare favorably with well-established immobilized Jørgensen-Hayashi catalysts, affording 5-hydroxyisoxazolidines as single diastereoisomers with high enantioselectivities and good yields (up to 83% yield, up to 99% ee). |