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Associations between objective sleep metrics and brain structure in cognitively unimpaired adults: interactions with sex and Alzheimer's biomarkers
INTRODUCTION: Sleep disturbances are prevalent in Alzheimer's disease (AD), probably emerging during its preclinical stage. Poor subjective sleep quality is linked to reduced brain volume and cortical thickness (CTh), ...
Clinical use and reporting of neurofilament quantification in neurological disorders: a global overview
Introduction: Neurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and ...
Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults
Introduction: Sleep dysfunction in those at higher risk of dementia may be associated with early structural changes to the hypothalamus. Methods: We used multivariate regression to analyze self-reported sleep (Pittsburgh ...
Diagnostic performance of plasma Aß42/40 ratio, p-tau181, GFAP, and NfL along the continuum of Alzheimer's disease and non-AD dementias: an international multi-center study
Introduction: Plasma phosphorylated tau (p-tau)181, glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), and amyloid beta ratio (Aß42/40) may have diagnostic and prognostic value in Alzheimer's ...
Heat-related mortality in Europe during 2024 and health emergency forecasting to reduce preventable deaths
Successive record-breaking summer temperatures, both globally and in Europe, raise the urgent question of how to better protect vulnerable populations. Here we quantified the heat-related mortality burden during the summers ...
The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) and its contributions to understanding Alzheimer's disease in Down syndrome: a decade of discovery
Down syndrome (DS) is a genetic form of Alzheimer's disease (AD) that offers crucial insights into AD pathogenesis. The Down Alzheimer Barcelona Neuroimaging Initiative (DABNI) is a population-based multimodal biomarker ...
Negotiated and negotiable? Contractual governance and the flexibility of the EU's recovery and resilience facility
Data de publicació electrònica: 16-02-2026
A strong regulator? The EU's uneven regulatory capacity in green industrial policy
The European Union (EU) has recently re-embraced industrial policy as a central instrument of economic governance, driven in particular by the challenges of climate change and intensifying geopolitical competition. This ...
Liaisons dangereuses: Britain, the US, the Soviet Union and the circulation of knowledge about penicillin (1943-1950)
Data de publicació electrònica: 28-11-2025
Did I have a dream last night? White dreaming as metacognitive feelings
Data de publicació electrònica: 22-01-2026
Could you please repeat it? The effect of language, and language variety on trust in multinational settings
Does the language or dialect used in political messages affect people's trust? While previous research has considered the question, little is known about how different languages and accents shape trust. Using an ...
Predicting hepatic decompensation in patients with metabolic dysfunction associated steatotic liver disease-related cirrhosis: the ABID-LSM Model
Background & aims: Predicting the risk of hepatic decompensation guides prognostication and therapy; however, it is challenging in patients with cirrhosis due to metabolic dysfunction-associated steatotic liver disease ...
¿Debe continuar el hidroxiisohexil 3-ciclohexeno carboxaldehído (Lyral®) en las baterías estándar de las pruebas epicutáneas?
Antecedentes y objetivo: El hidroxiisohexil 3-ciclohexeno carboxaldehído (HICC), o Lyral®, es un marcador de fragancias que forma parte de la mezcla de fragancias II (MF II), y aún se parchea como alérgeno independiente ...
Health outcomes of sarcopenia: a consensus report by the outcome working group of the Global Leadership Initiative in Sarcopenia (GLIS)
The Global Leadership Initiative in Sarcopenia (GLIS) aims to standardize the definition and diagnostic criteria for sarcopenia into one unifying, common classification. Among other actions to achieve this objective, the ...
Human iPSCs-based modeling unveils SETBP1 as a driver of chromatin rewiring in GATA2 deficiency
Patients with GATA2 deficiency are predisposed to developing myelodysplastic neoplasms (MDS), which can progress to acute myeloid leukemia. This progression is often associated with cytogenetic and somatic alterations. ...
Development as multidimensional environmental impoverishment
Poverty is multidimensional. Economic growth often implies environmental impoverishment and hence diminished options to choose valuable lives. People who are deprived of access to land, clean water and air because of ...
Exploring the contribution of migration city networks to policy learning in European cities: the case of Eurocities
As cities face growing challenges in managing migration and take on a more prominent role in addressing it, they increasingly turn to city networks (CNs) for collaboration. These networks provide opportunities for policy ...
Analysis methods for diagnosing rare neurodevelopmental diseases with episignatures: a systematic review of the literature
Background: Rare diseases (RDs) and neurodevelopmental disorders (NDDs) remain under-researched due to their low prevalence, leaving significant gaps in diagnostic strategies. Beyond next-generation sequencing, epigenetic ...
Building the plane while flying it: how projects serve to implement, pilot and co-create EU policy
Data de publicació electrònica: 09-01-2026
