Ciències Clíniques: Enviaments recents
Ara mostrant els elements 1-20 de 2299
Impacto del ejercicio intenso en los niveles de interleucina-6 en futbolistas semi-profesionales: un estudio comparativo entre adultos y niños.
El fútbol semi-profesional impone una gran demanda física, aumentando el riesgo de lesiones musculares debido a la acumulación de partidos y sesiones de entrenamiento con periodos de recuperación limitados. Este estudio ...
Mixed-model and transcriptome-wide association analyses identify transcription factors and genes associated with colorectal cancer susceptibility
Susceptibility transcription factors (TF) whose DNA bindings are altered by genetic variants regulating colorectal cancer (CRC) risk genes remain poorly defined. Using generalized linear mixed models, we analyze 218 TF ...
GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease
Background: Fibrotic interstitial lung diseases (ILDs) are characterized by different degrees of inflammation and fibrosis of the lung parenchyma that are associated with progressive loss of breath, high morbidity and ...
Quality of life and experience of patients with heart failure with preserved ejection fraction and their caregivers
Background/Objectives: Evidence of patient experiences with heart failure with preserved ejection fraction (HFpEF) and disease impact on quality of life (QoL) is scarce. This study explored perceived impacts on QoL and ...
Organ/space surgical site infection and long-term outcomes of rectal cancer surgery: retrospective population-based cohort study
Background: Anastomotic leak and subsequent organ/space surgical site infection (O/S-SSI) after colorectal cancer surgery are associated with poor short-term outcomes; however, the evidence regarding long-term outcomes is ...
Evidence and reality: an observational study on pharmacological outcomes in advanced head and neck tumors
The Catalan Institute of Oncology (ICO) is a comprehensive centre for the prevention, diagnosis, and treatment of cancer. At the institute, there is a set of institutional clinical practice guidelines, named ICOPraxis. The ...
Documento de consenso para la solicitud de pruebas de coagulación preoperatorias
Introduction: Standard pre-operative coagulation tests are insensitive to certain haemostatic abnormalities, yet they continue to be ordered routinely. Given the lack of clear guidance in Spain, we used Delphi methodology ...
Real-world patterns of immunoglobulin replacement therapy for infection prevention in common variable immunodeficiency: a multicenter nationwide study
Background and aims: Immunoglobulin replacement therapy (IgRT), administered intravenously (IVIg) or subcutaneously (SCIg), is the cornerstone treatment for patients with Common Variable Immunodeficiency (CVID). Although ...
Epcoritamab plus GemOx in transplant-ineligible relapsed/refractory DLBCL: results from the EPCORE NHL-2 trial
Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) have poor outcomes (complete response [CR] rates with standard salvage therapy gemcitabine plus oxaliplatin [GemOx], ∼30%; median overall ...
Co-creating a gamified tool for cannabis and tobacco use monitoring: Participant-driven development
Introduction: The growing use of cannabis, often alongside tobacco, presents challenges for substance use treatment programs (SUTPs), as it intensifies withdrawal symptoms. To address dual dependencies and improve engagement, ...
Impact of preoperative food addiction on weight loss and weight regain three years after bariatric surgery
Background: Food addiction (FA) is prevalent among individuals with severe obesity and has been associated with poorer weight loss (WL) outcomes after dietary interventions. However, its long-term impact after bariatric ...
EP11.01: Incidence and complications of obstructive sleep apnea in high-risk pregnancies
To describe the incidence during gestation of Obstructive Sleep Apnea (OSA) in cardiometabolic-risk pregnancies and to evaluate pregnancy complications due to OSA in these high-risk pregnancies.
Is antiparasitic treatment beneficial in chronic subarachnoid neurocysticercosis? A comparative case series
Background: Neurocysticercosis is particularly severe when affecting the subarachnoid space. While antiparasitic therapy effectively controls the infection, it can lead to significant complications, especially in subarachnoid ...
Altered resting-state functional connectivity in individuals at risk for Alzheimer’s disease: a longitudinal study
Background: Resting-state functional connectivity magnetic resonance imaging (rs-fMRI) is a sensitive tool for detecting early brain changes associated with Alzheimer's disease, even in its preclinical stages. Amnestic ...
Algoritmo para la asignación etiológica de la prematuridad
The etiology of preterm birth is difficult to classify. It is usually divided into three clinical types according to its clinical presentation: medically indicated; caused by ruptured membranes; and spontaneous or idiopathic. ...
Prenatal exposure to per- and polyfluoroalkyl substances, fetoplacental hemodynamics, and fetal growth
Introduction: The impact of legacy per- and polyfluoroalkyl substances (PFAS) on fetal growth has been well studied, but assessments of next-generation PFAS and PFAS mixtures are sparse and the potential role of fetoplacental ...
Clinical Correlates of Sports Betting: A Systematic Review
Sports betting is becoming increasingly widespread, and a growing number of individuals, both adolescents and adults, participate in this type of gambling. The main aim of this systematic review was to assess correlates ...
Effect of prenatal phthalate exposure on fetal development and maternal/neonatal health consequences: A systematic review
The ubiquitous presence of phthalate compounds in cosmetics, personal care products and plastics commonly used in toys, food packaging or household products, results in human exposure with adverse effects on reproductive ...
Allogeneic bone marrow transplantation in multiple myeloma
Background and Methods: In contrast to autologous bone marrow transplants for hematologic cancers, allogeneic transplants contain no tumor cells that might cause a relapse. We report the results of such allogeneic bone ...
Cediranib with mFOLFOX6 Versus Bevacizumab with mFOLFOX6 as first-line treatment for patients with advanced colorectal cancer: A double-blind, randomized phase II study (HORIZON III)
Purpose: To compare the efficacy of cediranib (a vascular endothelial growth factor receptor tyrosine kinase inhibitor [VEGFR TKI]) with that of bevacizumab (anti-VEGF-A monoclonal antibody) in combination with chemotherapy ...
