Ciències Fisiològiques: Enviaments recents
Ara mostrant els elements 121-140 de 824
Epigenetics in Cancer
Classic genetics alone cannot explain the diversity of phenotypes within a population. Nor does classic genetics explain how, despite their identical DNA sequences, monozygotic twins or cloned animals can have different ...
Obstructive apneas induce early activation of mesenchymal stem cells and enhancement of endothelial wound healing
Background: The aim was to test the hypothesis that the blood serum of rats subjected to recurrent airway obstructions mimicking obstructive sleep apnea (OSA) induces early activation of bone marrow-derived mesenchymal ...
Proceso de Bolonia (III): Educación en valores: profesionalismo
El desarrollo profesional y personal de los estudiantes de grado y de formación especializada como objetivo de la educación médica requiere disponer de definiciones normativas sobre el contenido y los contextos de los ...
DNA methylation polymorphisms precede any histological sign of atherosclerosis in mice lacking apolipoprotein E
The present work investigates the occurrence and significance of aberrant DNA methylation patterns during early stages of atherosclerosis. To this end, we asked whether the genetically atherosclerosis-prone APOE-null mice ...
F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local rhoA signaling in vivo
During immune surveillance and inflammation, leukocytes exit the vasculature through transient openings in the endothelium without causing plasma leakage. However, the exact mechanisms behind this intriguing phenomenon are ...
Retos de la formación médica de grado
Las Facultades de Medicina españolas han iniciado un nuevo proceso de reforma curricular en el marco de la implantación del Espacio Europeo de Educación Superior (EEES). Este proceso constituye, sin duda, una nueva ...
Integrin-Specific Mechanoresponses to Compression and Extension Probed by Cylindrical Flat-Ended AFM Tips in Lung Cells
Cells from lung and other tissues are subjected to forces of opposing directions that are largely transmitted through integrin-mediated adhesions. How cells respond to force bidirectionality remains ill defined. To address ...
Low input capture Hi-C (liCHi-C) identifies promoter-enhancer interactions at high-resolution
Long-range interactions between regulatory elements and promoters are key in gene transcriptional control; however, their study requires large amounts of starting material, which is not compatible with clinical scenarios ...
A Quantitative method for the characterization of lytic metastases of the bone from radiographic images
The aim of our study was to assess the diagnostic usefulness of the gray level parameters to distinguish osteolytic lesions using radiological images. Materials and Methods: A retrospective study was carried out. A total ...
In vivo analysis of DNA methylation patterns recognized by specific proteins: coupling CHIP and bisulfite analysis
The three-way connection between DNA methylation, chromatin configuration, and transcriptional regulation is under increasing attention, but the fine rules governing the epigenetic control are still poorly understood. In ...
Genetic predisposition to Alzheimer's disease is associated with enlargement of perivascular spaces in centrum semiovale region
This study investigated whether genetic factors involved in Alzheimer's disease (AD) are associated with enlargement of Perivascular Spaces (ePVS) in the brain. A total of 680 participants with T2-weighted MRI scans and ...
Canonical and non-canonical integrin-based adhesions dynamically interconvert
Adhesions are critical for anchoring cells in their environment, as signaling platforms and for cell migration. In line with these diverse functions different types of cell-matrix adhesions have been described. Best-studied ...
Calcineurin regulates skeletal muscle metabolism via coordinated changes in gene expression
The metabolic property of skeletal muscle adapts in response to an increased physiological demand by altering substrate utilization and gene expression. The calcium-regulated serine/threonine protein phosphatase calcineurin ...
Performance of mechanical ventilators at the patient's home: a multicentric quality control study
Background: Quality control procedures vary considerably among the providers of equipment for home mechanical ventilation (HMV). Methods: A multicentre quality control survey of HMV was performed at the home of 300 patients ...
Mechanical properties of cultured human airway smooth muscle cells from 0.05 to 0.4 Hz.
We investigated the rheological properties of living human airway smooth muscle cells in culture and monitored the changes in rheological properties induced by exogenous stimuli. We oscillated small magnetic microbeads ...
Actividades para promover la gestión crítica de la información de Internet aplicadas a estudiantes de farmacia
Con el fin de promover la adquisición de habilidades y destrezas que permitan al estudiante de Farmacia desarrollar una actitud activa y crítica frente a la información disponible en Internet, así como saber seleccionar ...
Comparación de estrategias de aprendizaje entre iguales: mientras los tutorados aprenden, los tutores consolidan sus conocimientos
Introducción: El aprendizaje entre iguales promueve que los estudiantes trabajen en grupos reducidos y puede ser una buena metodología para manejar la diversidad en el aula. Metodología: Se recogieron y compararon los ...
Structure and mechanisms of transport of human Asc1/CD98hc amino acid transporter
Recent cryoEM studies elucidated details of the structural basis for the substrate selectivity and translocation of heteromeric amino acid transporters. However, Asc1/CD98hc is the only neutral heteromeric amino acid ...
Microglial cells in astroglial cultures: a cautionary note
Primary rodent astroglial-enriched cultures are the most popular model to study astroglial biology in vitro. From the original methods described in the 1970's a great number of minor modifications have been incorporated ...
¿Por qué la simulación en la docencia de las ciencias de la salud sigue estando infrautilizada?
La simulación es la innovación docente que actualmente despierta más interés, ocupa habitualmente un lugar de honor en los programas de jornadas y actividades de innovación docente, y nos llena la boca y el tiempo de ...
