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Fonaments Clínics: Recent submissions

Now showing items 1-20 of 629

    Murine typhus as the leading cause of non-focalized fever in the Canary Islands 

    Vélez-Tobarias, Mónica; Torres-Vega, Ana María; Carmelo Pascual, Emma; Morais-Martín, Julio; Pérez, José Antonio; Gonzalo-Hernández. C.; Clot Razquin, Guillem; Ascaso Terrén, Carlos (Publication date: 2026-03-24)

    Purpose and methods: This prospective study aims to diagnose the etiology of non-focalized fever lasting between 5 and 28 days in the islands of La Palma and El Hierro (Canary Islands, Spain) during 2021, using serology ...

    Emotional intelligence and neurocognition profiles in first-episode psychosis: A two-year follow-up study 

    Clougher, Derek; Forte, Maria Florencia; Mezquida Mateos, Gisela; Sánchez Torres, Ana M.; Serra Navarro, Maria; Penadés Rubio, Rafael; Lobo, Antonio; González-Pinto, Ana; Panadero Gómez, Rocío; Roldán, Alexandra; Vieta i Pascual, Eduard, 1963-; Serna, Elena de la, 1978-; Trabsa, Amira; Martínez-Arán, Anabel, 1971-; Torrent Font, Carla; Tortorella, Alfonso; Menculini, Giulia; Ramos-Quiroga, Josep Antoni; Cuesta, Manuel J.; Bernardo Arroyo, Miquel; Amoretti Guadall, Silvia; PEPs Group (Publication date: 2025-10-09)

    Emotional intelligence (EI) and neurocognition (NC) impairments are common in first-episode psychosis (FEP), yet their evolution over time remains unclear. This study identified patient profiles in EI and NC performance ...

    Systems biology drug screening identifies statins as enhancers of current therapies in chronic lymphocytic leukemia 

    Gimenez, Neus; Tripathi, Rupal; Giró, Ariadna; Rosich, Laia; López Guerra, Mónica; López Oreja, Irene; Playa-Albinyana, Heribert; Arenas Ríos, Fabián; Mas, José Manuel; Pérez Galán, Patricia; Delgado, Julio (Delgado González); Campo Güerri, Elias; Farrés, Judith; Colomer Pujol, Dolors (Publication date: 2025-10-23)

    Chronic lymphocytic leukemia (CLL) is a B lymphoid malignancy highly dependent on the microenvironment. Despite new targeted therapies such as ibrutinib and venetoclax, disease progression and relapse remain an issue. CLL ...

    Challenges with Approved Targeted Therapies against Recurrent Mutations in CLL: A Place for New Actionable Targets 

    López Oreja, Irene; Playa-Albinyana, Heribert; Arenas Ríos, Fabián; López Guerra, Mónica; Colomer Pujol, Dolors (Publication date: 2025-09-26)

    Chronic lymphocytic leukemia (CLL) is characterized by a high degree of genetic variability and interpatient heterogeneity. In the last decade, novel alterations have been described. Some of them impact on the prognosis ...

    SF3B1 mutation-mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia 

    López Oreja, Irene; Gohr, Andre; Playa-Albinyana, Heribert; Giró, Ariadna; Arenas Ríos, Fabián; Higashi, Morihiro; Tripathi, Rupal; López Guerra, Mónica; Irimia Martínez, Manuel; Aymerich Gregorio, Marta; Valcárcel Juárez, Juan; Bonnal, Sophie; Colomer Pujol, Dolors (Publication date: 2025-11-12)

    Splicing factor 3B subunit 1 (SF3B1) is involved in pre-mRNA branch site recognition and is the target of antitumor-splicing inhibitors. Mutations in SF3B1 are observed in 15% of patients with chronic lymphocytic leukemia ...

    Imaging Efficacy of [18F]CTT1057 PET/CT in Patients with Biochemically Recurrent Prostate Cancer: Results from GuidePath-A Phase 3, Prospective Multicenter Study 

    Fanti, Stefano; Robles Barba, Javier Jesus; Behr, Spencer; Maurer, Tobias; Paredes Barranco, Pilar; Walz, Jochen; Duch, Joan; Simo Perdigo, Marc; Mainta, Ismini Charis; Bonnefoy, Pierre Benoit; Coulanges, Medge; Tang, Jun; Seigne, Christelle; Wilke, Celine; Catafau, Ana M.; Iagaru, Andrei; Aggarwal, Rahul (Publication date: 2025-09-25)

    Improved diagnostic accuracy in patients with prostate cancer at first biochemical recurrence (BCR) with low prostate-specific antigen (PSA) levels is needed. This prospective study (GuidePath; NCT04838613) aimed to evaluate ...

    A low total metabolic tumor volume independently predicts for a longer time to first treatment in initially observed, low tumor burden follicular lymphoma 

    Mozas, Pablo; Casanueva Eliceiry, Sebastián; Rivero, Andrea; Serna, Ángel; Simó, Marc; Rodríguez, Sonia; Rivas Delgado, Alfredo; Nadeu, Ferran; Correa, Juan Gonzalo; Piñeyroa, Juan Antonio; Pérez-Valencia, Amanda Isabel; Guinetti-Ortiz, Katia; Gómez-Hernando, Marta; Giné, Eva; Delgado, Julio; Villamor i Casas, Neus; Campo, Elías; Magnano, Laura; Abrisqueta Costa, Pau; Setoain Perego, Xavier; López-Guillermo, Aramando (Publication date: 2025-01-23)

    Watchful waiting is an acceptable management strategy for advanced-stage, low tumor burden (LTB) patients with follicular lymphoma (FL). However, the prediction of how long this treatment-free observation period will last ...

    Diagnóstico prequirúrgico de gliomas difusos en adultos: perspectivas prácticas de radiólogos de Unidades de neurooncología Post-WHO 2021 

    Pons Escoda, Albert; Majós Torró, Carlos; Smits, Marion; Oleaga Zufiría, Laura (Publication date: 2024-08-30)

    La Clasificación 2021 de tumores del sistema nervioso central (SNC) por la Organización Mundial de la Salud (OMS) fue acogida con entusiasmo, aunque al principio pudo parecer abrumadora. Con el tiempo, hemos comprendido ...

    Dissemination of NDM-producing Klebsiella pneumoniae and Escherichia coli high-risk clones in Catalan healthcare institutions 

    Marí Almirall, Marta; Cosgaya Castro, Clara; Pitart, Cristina; Viñes, Joaquim; Muñoz López, Laura; Campo, Irene; Cuscó, Anna; Rodríguez Serna, Laura; Santana, Gemina; Río, Ana del; Francino, Olga; Ciruela, Pilar; Pujol, Isabel; Ballester, Frederic; Marco, Francesc; Martínez Hernández, José Alfredo; Soriano Viladomiu, Alex; Vila Estapé, Jordi; Roca Subirà, Ignasi; MERCyCAT Study Group (Publication date: 2023-12-11)

    Objectives: To characterize the clonal spread of carbapenem-resistant Klebsiella pneumoniae and Escherichia coli isolates between different healthcare institutions in Catalonia, Spain. Methods: Antimicrobial susceptibility ...

    Halo sign in fetal cytomegalovirus infection: cerebral imaging abnormalities and postmortem histopathology in cohort of 35 infected fetuses. 

    Hawkins-Villarreal, Ameth; Castillo, Karen; Nadal Serra, Alfons; Planas i Marcé, Sílvia, 1965-; Moreno Espinosa, Ana L.; Alarcón, Ana; Rebollo Polo, Mónica; Figueras Retuerta, Francesc; Gratacós Solsona, Eduard; Eixarch Roca, Elisenda; Goncé Mellgren, Anna (Publication date: 2024-02-05)

    To evaluate the correlation of periventricular echogenic halo (halo sign) with histopathological findings and its association with other brain imaging abnormalities in fetuses with cytomegalovirus (CMV) infection.

    Genotypic and phenotypic study of antiviral resistance mutations in refractory cytomegalovirus infection 

    Santos Bravo, Marta; Nicolas Plault; Sánchez Palomino, Sonsoles; Rodríguez, Cristina; Navarro Gabriel, Mireia; Mosquera, María Mar; Fernández Avilés, Francesc; Suarez Lledó, María; Rovira, Montserrat; Bodro, Marta; Moreno Camacho, Ma. Asunción; Linares, Laura; Cofán Pujol, Federico; Berengua, Carla; Esteva, Cristina; Cordero, Elisa; Martín Dávila, Pilar; Aranzamendi, Maitane; Pérez Jiménez, Ana Belén; Vidal, Elisa; Fernández Sabé, Núria; Len, Óscar; Hantz, Sebastien; Alain, Sophie; Marcos, Ma. Angeles; the Spanish Network for Research in Infectious Diseases (REIPI); Group for the Study of Infection in Transplantation (GESITRA) (Publication date: 2023-12-04)

    Background This study describes the genotypic and phenotypic characterization of novel human cytomegalovirus (HCMV) genetic variants of a cohort of 94 clinically resistant HCMV patients. Methods and results ...

    Added value of intraoperative real-time imaging in searches for difficult-to-locate sentinel nodes. 

    Vidal i Sicart, Sergi; Paredes Barranco, Pilar; Zanón, Gabriel; Pahisa Fábregas, Jaume; Martinez-Román, Sergio; Caparrós, Xavier; Vilalta, Antoni; Rull Ortuño, Antonio Ramón; Pons Pons, Francisca (Publication date: 2013-02-07)

    Localization of sentinel lymph nodes can be challenging if they are in difficult anatomic locations or near high radiotracer activity The purpose of this study was to assess the value of intraoperative real-time imaging ...

    Trombosis venosas cerebrales en la edad pediátrica: presentación clínica, factores de riesgo, diagnóstico y tratamiento 

    Russi, Maria Eugenia; González, Verónica; Campistol Plana, Jaume (Publication date: 2013-01-16)

    Introducción: Desde su primera descripción a mediados del siglo xix, mucho se ha avanzado en el conocimiento de esta entidad, que constituye una reconocida, aunque desestimada, causa de ictus en la infancia. Objetivo: ...

    Modulation of neuronal signal transduction and memory formation by synaptic zinc 

    Sindreu Balet, Carlos; Storm, Daniel R. (Publication date: 2019-08-02)

    The physiological role of synaptic zinc has remained largely enigmatic since its initial detection in hippocampal mossy fibers over 50 years ago. The past few years have witnessed a number of studies highlighting the ability ...

    Draft Genome Sequence of JVAP01T, the Type Strain of the Novel Species Acinetobacter dijkshoorniae 

    Fernández Orth, Dietmar; Cosgaya Castro, Clara; Telli, Murat; Mosqueda, Noraida; Marí Almirall, Marta; Roca Subirà, Ignasi; Vila Estapé, Jordi (Publication date: 2017-02-03)

    Here, we report the draft genome sequence of the type strain of Acinetobacter dijkshoorniae, a novel human pathogen within the Acinetobacter calcoaceticus-Acinetobacter baumannii (ACB) ...

    Mutational status of nevus-associated melanomas. 

    Shitara, Danielle; Tell Martí, Gemma; Badenas Orquin, Celia; Enokihara, MM.; Alós i Hernández, Llúcia; Larque, A.B.; Michalany, Nilceo; Puig Butillé, Joan Anton; Carrera Álvarez, Cristina; Malvehy, J. (Josep); Puig i Sardà, Susana; Bagatin, E. (Publication date: 2017-02-09)

    Introduction Melanoma origin has always been a debated subject, as well as the role of adjacent melanocytic nevi. Epidemiological and histopathological studies point to melanomas arising either de novo or from a nevus. ...

    Loss of signalling via Gα13 in germinal center B-cell-derived lymphoma 

    Muppidi, Jagan R.; Schmitz, Roland; Green, Jesse A.; Xiao, Wenming; Larsen, Adrien B.; Braun, Sterling E.; An, Jinping; Xu, Ying; Rosenwald, Andreas; Ott, German; Gascoyne, Randy D.; Rimsza, Lisa; Campo Güerri, Elias; Jaffe, Elaine S.; Delabie, Jan; Smeland, Erlend B.; Braziel, Rita; Tubbs, Ray; Cook, James R.; Weisenburger, Dennis D.; Chan, Wing C.; Vaidehi, Nagarajan; Staudt, Louis M.; Cyster, Jason G. (Publication date: 2019-03-01)

    Germinal centre B-cell-like diffuse large B-cell lymphoma (GCB-DLBCL) is a common malignancy, yet the signalling pathways that are deregulated and the factors leading to its systemic dissemination are poorly defined1,2. ...

    Evaluation of a Loop-Mediated Isothermal Amplification Assay to Detect Carbapenemases Directly from Bronchoalveolar Lavage Fluid Spiked with Acinetobacter spp 

    Moreno Morales, Javier; Vergara Gómez, Andrea; Kostyanev, Tomislav; Rodríguez Baño, Jesús; Goossens, Herman; Vila Estapé, Jordi (Publication date: 2021-04-22)

    Carbapenem-resistant Acinetobacter spp. mainly Acinetobacter baumannii are frequently causing nosocomial infections with high mortality. In this study, the efficacy of the Eazyplex® SuperBug Complete A system, based on ...

    Pathogenic Acinetobacter species including the novel Acinetobacter dijkshoorniae recovered from market meat in Peru 

    Marí Almirall, Marta; Cosgaya Castro, Clara; Pons, María J.; Nemec, Alexandr; Ochoa, Theresa J.; Ruiz, Joaquim; Roca Subirà, Ignasi; Vila Estapé, Jordi (Publication date: 2021-06-25)

    Species of the Acinetobacter calcoaceticus-Acinetobacter baumannii complex are important human pathogens which can be recovered from animals and food, potential sources for their dissemination. The aim of the present study ...

    Virtual Model of the Internal Carotid Artery Classifications 

    Valera, Marc; Mavar Haramija, Marija; Puigdellívol Sánchez, Anna; Juanes Méndez, Juan Antonio; San Román, Luis; Notaris, Matteo de; Prats Galino, Alberto (Publication date: 2017-06-16)

    Interactive model developed from 3D reconstructions of human magnetic resonance (MR) images